Naydenova, Boyle and Pathe et al. report that Shigella uses the ubiquitin E3 ligase IpaH1.4 to evade lipopolysaccharide ubiquitylation in infected cells by degrading the host E3 ligase RNF213. Using cryo-electron microscopy, they present the structural basis of this interaction and the mechanism of immune evasion.
- Katerina Naydenova
- Keith B. Boyle
- Felix Randow
