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Dissecting the role of aberrant DNA methylation in human leukaemia

Chronic myeloid leukaemia is characterized by the genetic translocation t(9;22) encoding for BCR-ABL oncogene; however, the molecular mechanisms of disease progression are poorly understood. Here Amabile et al. show that aberrant methylation is promoted by BCR-ABL, driving the evolution of the disease.

Giovanni Amabile
Annalisa Di Ruscio
Daniel G. Tenen
Research22 May 2015
Nature Communications

Volume: 6, P: 1-10
The multisubunit active site of fumarase C from Escherichia coli

T.M. Weaver
D.G. Levitt
L.J. Banaszak
Research01 Aug 1995
Nature Structural Biology

Volume: 2, P: 654-662
Vascular endothelial growth factor enhances atherosclerotic plaque progression

Francesca L. Celletti
Jacob M. Waugh
Michael D. Dake
Research01 Apr 2001
Nature Medicine

Volume: 7, P: 425-429
Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children

Multisystem inflammatory syndrome in children (MIS-C) onsets in COVID-19 patients with manifestations similar to Kawasaki disease (KD). Here the author probe the peripheral blood transcriptome of MIS-C patients to find signatures related to natural killer (NK) cell activation and CD8+ T cell exhaustion that are shared with KD patients.

Noam D. Beckmann
Phillip H. Comella
Alexander W. Charney
ResearchOpen Access11 Aug 2021
Nature Communications

Volume: 12, P: 1-15
Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae

Transcriptomic analyses of acute phase whole blood from a large cohort of patients with COVID-19 identify molecular determinants of post-infection long-term sequelae.

Ryan C. Thompson
Nicole W. Simons
Noam D. Beckmann
ResearchOpen Access08 Dec 2022
Nature Medicine

Volume: 29, P: 236-246
DNMT1-interacting RNAs block gene-specific DNA methylation

RNAs are shown to interact with DNA methyltransferase 1 and prevent DNA methylation of genes at their specific locus, providing evidence that active transcription directly regulates DNA methylation levels.

Annalisa Di Ruscio
Alexander K. Ebralidze
Daniel G. Tenen
Research09 Oct 2013
Nature

Volume: 503, P: 371-376
C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence

How the characteristic quiescent status of adult HSCs is maintained is not well understood. Tenen and colleagues show that the transcription factor C/EBP is required to maintain a low proliferation rate in adult HSCs, partly through N-Myc repression.

Min Ye
Hong Zhang
Daniel G. Tenen
Research17 Mar 2013
Nature Cell Biology

Volume: 15, P: 385-394
Decent work and innovative work behavior of academic staff in higher education institutions: the mediating role of work engagement and job self-efficacy

Rasha S. Hassan
Hala M. G. Amin
Hebatallah Ghoneim
ResearchOpen Access30 May 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-19
Mutations of thyrotropin receptor isolated from thyroid autonomous functioning adenomas confer TSH-independent growth to thyroid cells

Antonio Porcellini
Germana Ruggiano
Enrico V Avvedimento
Research14 Aug 1997
Oncogene

Volume: 15, P: 781-789
In vivo and in vitro effects of cytokines and the hemoregulatory peptide dimer (pEEDCK)2 (pyroGlu-Glu-Asp-Cys-Lys)2 on Gα16-positive hematopoiesis

M Pfeilstöcker
H Karlic
R Heinz
Research16 Apr 1999
Leukemia

Volume: 13, P: 590-594
In squamous cell carcinoma of the vulva, overexpression of p53 is a late event and neither p53 nor mdm2 expression is a useful marker to predict lymph node metastases

A G Emanuels
J Koudstaal
H Hollema
ResearchOpen Access26 Mar 1999
British Journal of Cancer

Volume: 80, P: 38-43
Detection of cytogenetic aberrations both in CD90 (Thy-1)-positive and (Thy-1)-negative stem cell (CD34) subfractions of patients with acute and chronic myeloid leukemias

C Brendel
B Mohr
A Neubauer
Research03 Nov 1999
Leukemia

Volume: 13, P: 1770-1775
Molecular remission in PCR-positive acute myeloid leukemia patients with inv(16): role of bone marrow transplantation procedures

G Martinelli
E Ottaviani
S Tura
Correspondence10 Sept 1999
Bone Marrow Transplantation

Volume: 24, P: 694-697
Translisin recognition site sequences flank translocation breakpoints in a Philadelphia chromosome positive chronic myeloid leukemia patient expressing a novel type of chimeric BCR-ABL transcript (E8-INT-A2)

G Martinelli
C Terragna
S Tura
Correspondence07 Oct 1999
Leukemia

Volume: 13, P: 1635-1637
Concamitant expression of the rare E1/A3 and B2/A3 types of BCR/ABL transcript in a chronic myeloid leukemia (CML) patient

G Martinelli
M Amabile
S Tura
Correspondence09 Sept 1999
Leukemia

Volume: 13, P: 1463-1464
Long-term molecular complete remission with IFN-α in Ph+ adult acute lymphoid leukemia patients

P P Piccaluga
G Martinelli
G Visani
Correspondence14 Feb 2008
Leukemia

Volume: 22, P: 1617-1618
Growth inhibition, cytokinesis failure and apoptosis of multidrug-resistant leukemia cells after treatment with P-glycoprotein inhibitory agents

G Lehne
P De Angelis
HE Rugstad
Research14 May 1999
Leukemia

Volume: 13, P: 768-778
High-dose chemotherapy followed by reinfusion of selected CD34+ peripheral blood cells in patients with poor-prognosis breast cancer: a randomized multicentre study

C Chabannon
K Cornetta
P Viens
Research01 Oct 1998
British Journal of Cancer

Volume: 78, P: 913-921
Climate and Soil Characteristics Determine Where No-Till Management Can Store Carbon in Soils and Mitigate Greenhouse Gas Emissions

Stephen M. Ogle
Cody Alsaker
Gabriel G. Vazquez-Amabile
ResearchOpen Access12 Aug 2019
Scientific Reports

Volume: 9, P: 1-8
Quantification of BCR-ABL transcripts in CML patients in cytogenetic remission after interferon-α-based therapy

G Martinelli
N Testoni
S Tura
Research27 Mar 2000
Bone Marrow Transplantation

Volume: 25, P: 729-736
Alpha-interferon improves survival and remission duration in P-190^BCR-ABL positive adult acute lymphoblastic leukemia

G Visani
G Martinelli
S Tura
Research06 Jan 2000
Leukemia

Volume: 14, P: 22-27
Minocycline mitigates the effect of neonatal hypoxic insult on human brain organoids

Erin M. Boisvert
Robert E. Means
Samuel G. Katz
ResearchOpen Access11 Apr 2019
Cell Death & Disease

Volume: 10, P: 1-11
Erratum: Multiple sclerosis: getting personal with induced pluripotent stem cells

A Di Ruscio
F Patti
G Amabile
Amendments and Corrections14 Apr 2016
Cell Death & Disease

Volume: 7, P: e2185
Efficacy of very low dose perindopril 2 mg/indapamide 0.625 mg combination on left ventricular hypertrophy in hypertensive patients: the P.I.C.X.E.L. study rationale and design

P Gosse
O Dubourg
B Dahlöf
Research18 Sept 2002
Journal of Human Hypertension

Volume: 16, P: 653-659
CD34+/Ph+ cells are still detectable in chronic myeloid leukemia patients with sustained and prolonged complete cytogenetic remission during treatment with imatinib mesylate

M Bocchia
M Ippoliti
F Lauria
Correspondence09 Aug 2007
Leukemia

Volume: 22, P: 426-428
The Aurora B kinase activity is required for the maintenance of the differentiated state of murine myoblasts

G Amabile
A M D'Alise
R Cortese
Research31 Oct 2008
Cell Death & Differentiation

Volume: 16, P: 321-330
Multiple sclerosis: getting personal with induced pluripotent stem cells

A Di Ruscio
F Patti
G Amabile
ReviewsOpen Access09 Jul 2015
Cell Death & Disease

Volume: 6, P: e1806
Nuclear factor-erythroid 2 (NF-E2) expression in normal and malignant megakaryocytopoiesis

L Catani
N Vianelli
M Baccarani
Research30 Aug 2002
Leukemia

Volume: 16, P: 1773-1781
Induced pluripotent stem cells in hematology: current and future applications

D Focosi
G Amabile
M Pistello
ReviewsOpen Access09 May 2014
Blood Cancer Journal

Volume: 4, P: e211
TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells

M Bartucci
R Dattilo
R De Maria
Research17 Feb 2014
Oncogene

Volume: 34, P: 681-690
Molecular monitoring of acute myeloid leukemia associated with inv(16): threshold of CBFβ/MYH11 transcript copy number above which relapse occurs and below which continuous Complete Remission is likely

G Martinelli
S Buonamici
M Baccarani
Correspondence19 Mar 2003
Leukemia

Volume: 17, P: 650-651
Imatinib therapy for chronic myeloid leukemia patients who relapse after allogeneic stem cell transplantation: a molecular analysis

F Palandri
M Amabile
M Baccarani
Correspondence08 Jan 2007
Bone Marrow Transplantation

Volume: 39, P: 189-191
Efficacy of imatinib mesylate (STI571) in conjunction with alpha-interferon: long-term quantitative molecular remission in relapsed P-190^BCR-ABL-positive acute lymphoblastic leukemia

G Visani
A Isidori
M Baccarani
Correspondence02 Oct 2002
Leukemia

Volume: 16, P: 2159-2160
Dual tyrosine kinase inhibitors in chronic myeloid leukemia

G Martinelli
S Soverini
M Baccarani
Reviews22 Sept 2005
Leukemia

Volume: 19, P: 1872-1879

Search

Dissecting the role of aberrant DNA methylation in human leukaemia

The multisubunit active site of fumarase C from Escherichia coli

Vascular endothelial growth factor enhances atherosclerotic plaque progression

Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children

Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae

DNMT1-interacting RNAs block gene-specific DNA methylation

C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence

Decent work and innovative work behavior of academic staff in higher education institutions: the mediating role of work engagement and job self-efficacy

Mutations of thyrotropin receptor isolated from thyroid autonomous functioning adenomas confer TSH-independent growth to thyroid cells

In vivo and in vitro effects of cytokines and the hemoregulatory peptide dimer (pEEDCK)2 (pyroGlu-Glu-Asp-Cys-Lys)2 on Gα16-positive hematopoiesis

In squamous cell carcinoma of the vulva, overexpression of p53 is a late event and neither p53 nor mdm2 expression is a useful marker to predict lymph node metastases

Detection of cytogenetic aberrations both in CD90 (Thy-1)-positive and (Thy-1)-negative stem cell (CD34) subfractions of patients with acute and chronic myeloid leukemias

Molecular remission in PCR-positive acute myeloid leukemia patients with inv(16): role of bone marrow transplantation procedures

Translisin recognition site sequences flank translocation breakpoints in a Philadelphia chromosome positive chronic myeloid leukemia patient expressing a novel type of chimeric BCR-ABL transcript (E8-INT-A2)

Concamitant expression of the rare E1/A3 and B2/A3 types of BCR/ABL transcript in a chronic myeloid leukemia (CML) patient

Long-term molecular complete remission with IFN-α in Ph+ adult acute lymphoid leukemia patients

Growth inhibition, cytokinesis failure and apoptosis of multidrug-resistant leukemia cells after treatment with P-glycoprotein inhibitory agents

High-dose chemotherapy followed by reinfusion of selected CD34+ peripheral blood cells in patients with poor-prognosis breast cancer: a randomized multicentre study

Climate and Soil Characteristics Determine Where No-Till Management Can Store Carbon in Soils and Mitigate Greenhouse Gas Emissions

Quantification of BCR-ABL transcripts in CML patients in cytogenetic remission after interferon-α-based therapy

Alpha-interferon improves survival and remission duration in P-190^BCR-ABL positive adult acute lymphoblastic leukemia

Minocycline mitigates the effect of neonatal hypoxic insult on human brain organoids

Erratum: Multiple sclerosis: getting personal with induced pluripotent stem cells

Efficacy of very low dose perindopril 2 mg/indapamide 0.625 mg combination on left ventricular hypertrophy in hypertensive patients: the P.I.C.X.E.L. study rationale and design

CD34+/Ph+ cells are still detectable in chronic myeloid leukemia patients with sustained and prolonged complete cytogenetic remission during treatment with imatinib mesylate

The Aurora B kinase activity is required for the maintenance of the differentiated state of murine myoblasts

Multiple sclerosis: getting personal with induced pluripotent stem cells

Nuclear factor-erythroid 2 (NF-E2) expression in normal and malignant megakaryocytopoiesis

Induced pluripotent stem cells in hematology: current and future applications

TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells

Molecular monitoring of acute myeloid leukemia associated with inv(16): threshold of CBFβ/MYH11 transcript copy number above which relapse occurs and below which continuous Complete Remission is likely

Imatinib therapy for chronic myeloid leukemia patients who relapse after allogeneic stem cell transplantation: a molecular analysis

Efficacy of imatinib mesylate (STI571) in conjunction with alpha-interferon: long-term quantitative molecular remission in relapsed P-190^BCR-ABL-positive acute lymphoblastic leukemia

Dual tyrosine kinase inhibitors in chronic myeloid leukemia

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