Nature Search

Genetic loci influencing kidney function and chronic kidney disease

John Chambers and colleagues identify common variants at four loci associated with serum creatinine levels, a marker of kidney function. Their findings provide insight into the pathways underlying susceptibility to chronic kidney disease.

John C Chambers
Weihua Zhang
Jaspal S Kooner
Research11 Apr 2010
Nature Genetics

Volume: 42, P: 373-375
Ancient Iron Nails well preserved from Apparently Corrosive Soils

G. H. BOOTH
A. K. TILLER
F. WORMWELL
Research28 Jul 1962
Nature

Volume: 195, P: 376-377
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

Within-sibship genome-wide association analyses using data from 178,076 siblings illustrate differences between population-based and within-sibship GWAS estimates for phenotypes influenced by demographic and indirect genetic effects.

Laurence J. Howe
Michel G. Nivard
Neil M. Davies
ResearchOpen Access09 May 2022
Nature Genetics

Volume: 54, P: 581-592
Thorium Determination in Glasses using Fission Track Technique

G. M. REIMER
B. S. CARPENTER
Research11 Jan 1974
Nature

Volume: 247, P: 101-102
Acquired Resistance to Chloroquine Diphosphate in P. gallinaceum in Chicks

A. P. RAY
G. K. SHARMA
Research08 Dec 1956
Nature

Volume: 178, P: 1291-1292
Engineering Applications of Rubbers

L. R. G. TRELOAR
Books & Arts27 Nov 1965
Nature

Volume: 208, P: 823
Network Thermodynamics

G. OSTER
A. PERELSON
A. KATCHALSKY
Research09 Jun 1972
Nature

Volume: 237, P: 332-333
Effect of electric fields on growth rate of embryonic chick tibiae in vitro

JOSEPH WATSON
WILLIAM G. DE HAAS
SONIA S. HAUSER
Research27 Mar 1975
Nature

Volume: 254, P: 331-332
Microstructure of High Strength, High Modulus Carbon Fibres

D. V. BADAMI
J. C. JOINER
G. A. JONES
Research22 Jul 1967
Nature

Volume: 215, P: 386-387
A New Type of Diffusion Cathode

A. H. BECK
A. B. CUTTING
G. KING
Research27 Nov 1954
Nature

Volume: 174, P: 1010-1011
The Indo-Pacific Loggerhead Turtle in Tasmanian Waters

E. O. G. SCOTT
B. C. MOLLISON
Research18 Aug 1956
Nature

Volume: 178, P: 372
Time and mode of fusion of human fibroblasts treated with polyethylene glycol (PEG)

G. PONTECORVO
P. N. RIDDLE
ANNE HALES
Research20 Jan 1977
Nature

Volume: 265, P: 257-258
Dosage–Mortality Curves for Houseflies Susceptible and Resistant to DDT

K. WILSON-JONES
G. DAVIDSON
Research09 Aug 1958
Nature

Volume: 182, P: 403-404
Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition

Rodney E. Phillips
Sarah Rowland-Jones
Andrew J. McMichael
Research12 Dec 1991
Nature

Volume: 354, P: 453-459
Seismological evidence for shallow crystalline basement in Southern Uplands, Scotland

G. J. H. OLIVER
W. S. MCKERROW
Research03 May 1984
Nature

Volume: 309, P: 89
Enzymatic Determination in Serum of Lathyritic and Prednisone-treated Lathyritic Rats

G. W. KORTING
H. HOLZMANN
B. MORSCHES
Research12 Mar 1966
Nature

Volume: 209, P: 1130
Extraneous X-Ray Diffraction Patterns from Algal Flagella

W. T. ASTBURY
F. G. E. PAUTARD
Research18 Aug 1956
Nature

Volume: 178, P: 372
In vivo imaging of virological synapses

In vitro, retroviruses spread between cells via structures resembling synapses. Sewaldet al. now demonstrate that virological synapses can also be observed in living mice by intravital microscopy, validating this concept in vivo.

Xaver Sewald
David G. Gonzalez
Walther Mothes
Research27 Dec 2012
Nature Communications

Volume: 3, P: 1-9
Associations of autozygosity with a broad range of human phenotypes

Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

David W Clark
Yukinori Okada
James F Wilson
ResearchOpen Access31 Oct 2019
Nature Communications

Volume: 10, P: 1-17
Drug-Resistance Shown by Trypanosomes Following 'Antrycide' Treatment

S. G. WILSON
Research04 Jun 1949
Nature

Volume: 163, P: 873-874
Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62^TCF

R. A. Hipskind
V. N. Roa
A. Nordheim
Research26 Dec 1991
Nature

Volume: 354, P: 531-534
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Freezing as an Aid in the Drying and Purification of Humus and Allied Materials

W. G. C. FORSYTH
G. K. FRASER
Research01 Nov 1947
Nature

Volume: 160, P: 607
Influence of Streptomycin and Mineral Salts in the Action of Ribonuclease

G. CERIOTTI
Research04 Jun 1949
Nature

Volume: 163, P: 874
In vitro transformation of cultured cells from Nicotiana tabacum by Agrobacterium tumefaciens

L. MÁRTON
G. J. WULLEMS
R. A. SCHILPEROORT
Research01 Jan 1979
Nature

Volume: 277, P: 129-131
Transcurrent faulting and the anomalous position of pre-Carboniferous Anglesey

M. J. C. Nutt
E. G. Smith
Research09 Apr 1981
Nature

Volume: 290, P: 492-495
C–H functionalization: Access to arylomycin antibiotics

C–H functionalization logic has enabled rapid synthetic access to arylomycin antibiotics which could lead to the identification of new broad-spectrum antibiotics.

Stephen G. Davey
Research Highlights07 Mar 2018
Nature Reviews Chemistry

Volume: 2, P: 1
Polymer metamorphosis

A rearrangement reaction — a classic of traditional organic synthesis — has been applied to a polymer, enabling conversion of a polyester to a vinyl polymer.

Stephen G. Davey
Research Highlights22 Dec 2021
Nature Reviews Chemistry

Volume: 6, P: 6
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

Genome-wide association analyses of intracranial and nine subcortical brain volumes in 74,898 participants of European ancestry identify 254 independent loci and yield polygenic scores accounting for brain variation across ancestries.

Luis M. García-Marín
Adrian I. Campos
Miguel E. Rentería
Research21 Oct 2024
Nature Genetics

Volume: 56, P: 2333-2344
Retinoblastoma—origin from a primitive neuroectodermal cell?

A. P. Kyritsis
M. Tsokos
G. J. Chader
Research02 Feb 1984
Nature

Volume: 307, P: 471-473
Tricyclic oxonium tamed

An elusive and highly reactive intermediate has been prepared and characterized, ultimately leading to the synthesis of ten natural products.

Stephen G. Davey
Research Highlights13 Nov 2019
Nature Reviews Chemistry

Volume: 3, P: 669
Remodelling (R)-carvone

A total synthesis of xishacorene B starts from a chiral pool molecule and exploits a C–C activation reaction to form the core structure.

Stephen G. Davey
Research Highlights24 Aug 2018
Nature Reviews Chemistry

Volume: 2, P: 199
Rat × rat hybrid myelomas and a monoclonal anti-Fd portion of mouse IgG

G. GALFRÈ
C. MILSTEIN
B. WRIGHT
Research01 Jan 1979
Nature

Volume: 277, P: 131-133
Dairying, diseases and the evolution of lactase persistence in Europe

Examination of archaeological pottery residues and modern genes suggest that environmental conditions, subsistence economics and pathogen exposure may explain selection for lactase persistence better than prehistoric consumption of milk.

Richard P. Evershed
George Davey Smith
Mark G. Thomas
Research27 Jul 2022
Nature

Volume: 608, P: 336-345
Lack of Effect of Histidine on Rabbit Atheromatosis

G. G. PINTER
D. B. ZILVERSMIT
Research02 May 1959
Nature

Volume: 183, P: 1272
An alternate route to selectivity

Rapidly alternating the polarity of electrodes offers a new opportunity for synthetic chemists to obtain selective reaction outcomes in organic electrosynthesis.

Stephen G. Davey
Research Highlights17 Nov 2021
Nature Reviews Chemistry

Volume: 5, P: 837
Habenula contributions to negative self-cognitions

Self-related cognitions are central to identity and wellbeing. Using 7-Tesla MRI, Kung et al map a dynamic network centred on the habenula demonstrating its role in encoding self-directed thinking and adaptive responses to negative self-cognitions.

Po-Han Kung
Matthew D. Greaves
Trevor Steward
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-15
Possible Role of Birds in the Maintenance of Yellow Fever in West Africa

G. M. FINDLAY
T. A. COCKBURN
Research28 Aug 1943
Nature

Volume: 152, P: 245
Idarubicin DNA intercalation is reduced by MRP1 and not Pgp

MEP Smeets
RAP Raymakers
TM de Witte
Research09 Sept 1999
Leukemia

Volume: 13, P: 1390-1398
Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection

The response to infectious and inflammatory challenges differs among people but the reasons for this are poorly understood. Here the authors explore the impact of variables such as age, sex, and the capacity for controlling inflammation and maintaining immunocompetence, linking this capacity to favourable health outcomes and lifespan.

Sunil K. Ahuja
Muthu Saravanan Manoharan
Weijing He
ResearchOpen Access13 Jun 2023
Nature Communications

Volume: 14, P: 1-31
Genetic insights into biological mechanisms governing human ovarian ageing

Hundreds of genetic loci associated with age at menopause, combined with experimental evidence in mice, highlight mechanisms of reproductive ageing across the lifespan.

Katherine S. Ruth
Felix R. Day
John R. B. Perry
Research04 Aug 2021
Nature

Volume: 596, P: 393-397
Molecular mechanism of IKK catalytic dimer docking to NF-κB substrates

The inhibitor of kB kinase (IKK) is a central regulator of NF-kB signalling. Here the authors identify a motif conserved in substrates of canonical and alternative NF-kB pathways which mediates docking to catalytic IKK dimers: they show that phosphorylation of the conserved tyrosine suppresses the docking interaction.

Changqing Li
Stefano Moro
Katia Zanier
ResearchOpen Access03 Sept 2024
Nature Communications

Volume: 15, P: 1-19
Changing the rings

A new route to the aglycone core of the anthracycline idarubicin relies on the global functionalization of tetracene rather than annulation reactions.

Stephen G. Davey
Research Highlights22 Jul 2019
Nature Reviews Chemistry

Volume: 3, P: 462
Activation of the NADPH oxidase involves the small GTP-binding protein p21^rac1

Arie Abo
Edgar Pick
Anthony W. Segal
Research17 Oct 1991
Nature

Volume: 353, P: 668-670
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Multi-ancestry meta-analyses of genome-wide association studies for self-reported physical activity during leisure time, leisure screen time, sedentary commuting and sedentary behavior at work identify 99 loci associated with at least one of these traits.

Zhe Wang
Andrew Emmerich
Marcel den Hoed
ResearchOpen Access07 Sept 2022
Nature Genetics

Volume: 54, P: 1332-1344
Spontaneous shedding and antibody induced modulation of histocompatibility antigens on murine lymphomata: Correlation with metastatic capacity

G C Davey
G A Currie
P Alexander
Research01 Jan 1976
British Journal of Cancer

Volume: 33, P: 9-14
Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses

Family-based study designs have been applied to resolve confounding by population stratification, dynastic effects and assortative mating in genetic association analyses. Here, Brumpton et al. describe theory and simulations for overcoming such biases in Mendelian randomization through within-family studies.

Ben Brumpton
Eleanor Sanderson
Neil M. Davies
ResearchOpen Access14 Jul 2020
Nature Communications

Volume: 11, P: 1-13
Class II MHC molecules can use the endogenous pathway of antigen presentation

Jed G. Nuchtern
William E. Biddison
Richard D. Klausner
Research04 Jan 1990
Nature

Volume: 343, P: 74-76
Quantifying the causal impact of biological risk factors on healthcare costs

Understanding the causal impact that risk factors have on healthcare cost is critical to evaluate healthcare interventions. Here, authors show that waist circumference, body mass index, and blood pressure have robust causal impact on healthcare cost.

Jiwoo Lee
Sakari Jukarainen
Andrea Ganna
ResearchOpen Access13 Sept 2023
Nature Communications

Volume: 14, P: 1-11
Regeneration of transgenic cassava plants (Manihot esculenta Crantz) from microbombarded embryogenic suspension cultures

Christian Schöpke
Nigel Taylor
Claude Fauquet
Research01 Jun 1996
Nature Biotechnology

Volume: 14, P: 731-735

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