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Showing 1–50 of 86 results

Advanced filters: Author: G Rossetti Clear advanced filters

Binding pose depth modulates photoswitchable ligands’ efficacy at the 5-HT_2A receptor

Photoswitchable ligands can reversibly modulate receptor activity upon light-induced isomerization, yet the impact of structural changes on efficacy is not well understood. Here, the authors use molecular dynamics simulations to investigate two azobenzene-based 5–HT2A receptor ligands with different methoxy substituent positions, revealing that ligand insertion depth into the binding pocket is a crucial determinant of efficacy.

Verena Weber
Giacomo Salvadori
Giulia Rossetti
ResearchOpen Access12 Feb 2026
Communications Chemistry

P: 1-11
Capturing disease severity in LIS1-lissencephaly reveals proteostasis dysregulation in patient-derived forebrain organoids

Here authors used patient-derived forebrain organoids to reveal how LIS1 mutations cause varying severity in a neurodevelopmental disorder, uncovering links between cytoskeletal defects, protein stress, and potential therapeutic strategies.

Lea Zillich
Matteo Gasparotto
Julia Ladewig
ResearchOpen Access13 Oct 2025
Nature Communications

Volume: 16, P: 1-16
Conformation of Acetylcholine

F. G. CANEPA
E. F. MOONEY
Research03 Jul 1965
Nature

Volume: 207, P: 78-79
The role of endogenous nerve growth factor in human diabetic neuropathy

P. Anand
G. Terenghi
D.V. Sinicropi
Research01 Jun 1996
Nature Medicine

Volume: 2, P: 703-707
Transcription–replication conflicts underlie sensitivity to PARP inhibitors

Poly(ADP-ribose) polymerase 1 (PARP1) functions together with TIMELESS and TIPIN to protect the replisome in early S phase from transcription–replication conflicts, and inhibiting PARP1 enzymatic activity may suffice for treatment efficacy in homologous recombination-deficient settings.

Michalis Petropoulos
Angeliki Karamichali
Thanos D. Halazonetis
ResearchOpen Access20 Mar 2024
Nature

Volume: 628, P: 433-441
Functional MRI evidence for adult motor cortex plasticity during motor skill learning

Avi Kami
Gundela Meyer
Leslie G. Ungerleider
Research14 Sept 1995
Nature

Volume: 377, P: 155-158
Decreasing Striatal 6-FDOPA Uptake with Increasing Duration of Cocaine Withdrawal

Joseph C Wu
Kate Bell
William E Bunney
Research01 Dec 1997
Neuropsychopharmacology

Volume: 17, P: 402-409
Short-term changes in the base neutralizing capacity of an acid Adirondack lake, New York

C. T. Driscoll
G. C. Schafran
Research26 Jul 1984
Nature

Volume: 310, P: 308-310
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Hybrid 3D-printed/electrospun scaffolds drive myogenic differentiation of mesenchymal stem cells (MSCs)

Silvia Pisani
Stefania Marconi
Bice Conti
ResearchOpen Access21 Dec 2025
Scientific Reports

Volume: 16, P: 1-15
The Psychology of Cultural Change in Painting

F. IAN G. RAWLINS
Books & Arts10 Jul 1943
Nature

Volume: 152, P: 31-33
An ‘automatic pilot’ for the hand in human posterior parietal cortex: toward reinterpreting optic ataxia

L. Pisella
H. Gréa
Y. Rossetti
Research01 Jul 2000
Nature Neuroscience

Volume: 3, P: 729-736
Racial Dwarfs in the Pyrenees

R. G. HALIBURTON
Research26 Jan 1893
Nature

Volume: 47, P: 294-295
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

FXR regulates the levels of ACE2 in tissues of the respiratory and gastrointestinal systems that are affected by COVID-19, and inhibiting FXR with ursodeoxycholic acid downregulates ACE2 and reduces susceptibility to SARS-CoV-2 infection.

Teresa Brevini
Mailis Maes
Fotios Sampaziotis
ResearchOpen Access05 Dec 2022
Nature

Volume: 615, P: 134-142
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

Silvana Obici
Zhaohui Feng
Luciano Rossetti
Research20 May 2002
Nature Neuroscience

Volume: 5, P: 566-572
Dante's “Quæstio de Aqua et Terra”

EDMUND G. GARDNER
Editorial26 Jan 1893
Nature

Volume: 47, P: 295-298
Autologous bone marrow transplantation for childhood acute lymphoblastic leukaemia in Italy

C Messina
S Cesaro
L Zanesco
Research14 May 1998
Bone Marrow Transplantation

Volume: 21, P: 1015-1021
Modeling the allosteric modulation on a G-Protein Coupled Receptor: the case of M2 muscarinic Acetylcholine Receptor in complex with LY211960

L. Maggi
P. Carloni
G. Rossetti
ResearchOpen Access20 Feb 2020
Scientific Reports

Volume: 10, P: 1-9
Genetic mechanisms of critical illness in COVID-19

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Erola Pairo-Castineira
Sara Clohisey
J. Kenneth Baillie
Research11 Dec 2020
Nature

Volume: 591, P: 92-98
A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells

Germline mutations in BRCA1 or BRCA2 tumour suppressor genes predispose to different cancers, as does oncogene activation. Here the authors reveal that aberrant transcription of specific genes triggered by activation of the oncogene β-catenin causes replication failure and cell death in the context of BRCA1/2 deficiency.

Rebecca A. Dagg
Gijs Zonderland
Madalena Tarsounas
ResearchOpen Access13 Aug 2021
Nature Communications

Volume: 12, P: 1-17
Evidence for light-by-light scattering in heavy-ion collisions with the ATLAS detector at the LHC

Quantum electrodynamics predicts a rare process in which light is scattered by light. The ATLAS Collaboration reports signs of this elusive effect in the collisions of ultra-relativistic lead ions.

M. Aaboud
G. Aad
L. Zwalinski
ResearchOpen Access14 Aug 2017
Nature Physics

Volume: 13, P: 852-858
Measurement of the inelastic proton–proton cross-section at √s=7 TeV with the ATLAS detector

The measurement of the total cross-section of proton–proton collisions is of fundamental importance for particle physics. Here, the first measurement of the inelastic cross-section is presented for proton–proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access06 Sept 2011
Nature Communications

Volume: 2, P: 1-14
Luis Izquierdo

D. G. Whittingham
C. Barros
Correspondence18 Feb 1993
Nature

Volume: 361, P: 578
Global diversity and biogeography of bacterial communities in wastewater treatment plants

Global sampling of microbial communities associated with wastewater treatment plants and application of ecological theory revealed a small, core bacterial community associated with performance and provides insights into the community dynamics in this environment.

Linwei Wu
Daliang Ning
Jizhong Zhou
Research13 May 2019
Nature Microbiology

Volume: 4, P: 1183-1195
Automated Protein Biomarker Analysis: on-line extraction of clinical samples by Molecularly Imprinted Polymers

Cecilia Rossetti
Magdalena A. Świtnicka-Plak
Léon Reubsaet
ResearchOpen Access17 Mar 2017
Scientific Reports

Volume: 7, P: 1-11
Genotype Influences In Vivo Dopamine Transporter Availability in Human Striatum

Andreas Heinz
David Goldman
Daniel R Weinberger
Research01 Feb 2000
Neuropsychopharmacology

Volume: 22, P: 133-139
Autologous bone marrow transplantation for treatment of isolated central nervous system relapse of childhood acute lymphoblastic leukemia

C Messina
MG Valsecchi
L Zanesco
Research13 Feb 1998
Bone Marrow Transplantation

Volume: 21, P: 9-14
SGLT2 inhibition — a novel strategy for diabetes treatment

Preventing the reabsorption of glucose in the kidney by inhibiting the sodium–glucose co-transporters (SGLTs) is emerging as a promising new strategy to treat type 2 diabetes. Here, Chao and Henry give an overview of the role of the kidney in glucose homeostasis and discuss the development and potential of SGLT2-selective inhibitors, reviewing those agents currently undergoing clinical investigation.

Edward C. Chao
Robert R. Henry
Reviews28 May 2010
Nature Reviews Drug Discovery

Volume: 9, P: 551-559
Feature-rich multiplex lexical networks reveal mental strategies of early language learning

Salvatore Citraro
Michael S. Vitevitch
Giulio Rossetti
ResearchOpen Access26 Jan 2023
Scientific Reports

Volume: 13, P: 1-12
A Banker Naturalist

A. G.
News04 Aug 1904
Nature

Volume: 70, P: 327-328
Substrate competition and insulin action in animal models

R Vettor
AM Lombardi
G Federspil
Research24 Jul 2000
International Journal of Obesity

Volume: 24, P: S22-S24
Reimagining clinical AI: from clickstreams to clinical insights with EHR use metadata

Chao Yan
Xinmeng Zhang
You Chen
ReviewsOpen Access04 Sept 2025
npj Health Systems

Volume: 2, P: 1-10
A first update on mapping the human genetic architecture of COVID-19

Gita A. Pathak
Juha Karjalainen
J. Kenneth Baillie
ResearchOpen Access03 Aug 2022
Nature

Volume: 608, P: E1-E10
Behavioral and Biochemical Manifestations of Mecamylamine-Precipitated Nicotine Withdrawal in the Rat: Role of Nicotinic Receptors in the Ventral Tegmental Area

Bengt E Hildebrand
George Panagis
George G Nomikos
Research01 Oct 1999
Neuropsychopharmacology

Volume: 21, P: 560-574
Chronic Ethanol Exposure and Protracted Abstinence Alter NMDA Receptors in Central Amygdala

Marisa Roberto
Michal Bajo
George R Siggins
Research27 Jul 2005
Neuropsychopharmacology

Volume: 31, P: 988-996
Effects of sustained daily latanoprost application on anterior chamber anatomy and physiology in mice

Laura M. Dutca
Danielle Rudd
Michael G. Anderson
ResearchOpen Access30 Aug 2018
Scientific Reports

Volume: 8, P: 1-13
Acute effects of leptin on glucose metabolism of in situ rat perfused livers and isolated hepatocytes

RB Ceddia
G Lopes
R Curi
Research11 Nov 1999
International Journal of Obesity

Volume: 23, P: 1207-1212
Plasma nitrate plus nitrite changes during continuous intravenous infusion interleukin 2

G Citterio
F Pellegatta
C Rugarli
Research01 Oct 1996
British Journal of Cancer

Volume: 74, P: 1297-1301
Diagnosis of persistent ovarian carcinoma with three-step immunoscintigraphy

P Magnani
F Fazio
G Paganelli
ResearchOpen Access07 Jan 2000
British Journal of Cancer

Volume: 82, P: 616-620
Germline mutations of the APC gene in Korean familial adenomatous polyposis patients

Yong-Jin Won
Kyu Joo Park
J.-G. Park
Research01 Mar 1999
Journal of Human Genetics

Volume: 44, P: 103-108
Immunochemical vs guaiac faecal occult blood tests in a population-based screening programme for colorectal cancer

G Castiglione
M Zappa
S Ciatto
Research01 Jul 1996
British Journal of Cancer

Volume: 74, P: 141-144
Second allogeneic bone marrow transplantation in acute leukemia: a multicenter study from the Gruppo Italiano Trapianto Di Midollo Osseo (GITMO)

A Bosi
S Bacci
A Amici
Research01 Mar 1997
Leukemia

Volume: 11, P: 420-424
Effect of raloxifene on IGF-I and IGFBP-3 in postmenopausal women with breast cancer

R Torrisi
L Baglietto
A Decensi
ResearchOpen Access11 Dec 2001
British Journal of Cancer

Volume: 85, P: 1838-1841
Interleukin-7-enhanced cytotoxic T lymphocyte activity after viral infection in marrow transplanted mice

A Abdul-Hai
A Ben-Yehuda
R Or
Research01 Mar 1997
Bone Marrow Transplantation

Volume: 19, P: 539-543
Treatment of acute graft-versus-host disease with PUVA (psoralen and ultraviolet irradiation): results of a pilot study

A Wiesmann
A Weller
H Einsele
Research01 Feb 1999
Bone Marrow Transplantation

Volume: 23, P: 151-155
A digital reconstruction of the 1630–1631 large plague outbreak in Venice

Gianrocco Lazzari
Giovanni Colavizza
Marcel Salathé
ResearchOpen Access20 Oct 2020
Scientific Reports

Volume: 10, P: 1-7
Effects of dietary restriction on serum leptin concentration in obese women

F Cella
GF Adami
R Cordera
Research26 May 1999
International Journal of Obesity

Volume: 23, P: 494-497
Long-term results after allogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic phase: a report from the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation

F van Rhee
RM Szydlo
A Gratwohl
Research01 Oct 1997
Bone Marrow Transplantation

Volume: 20, P: 553-560
Mass media impact on opinion evolution in biased digital environments: a bounded confidence model

Valentina Pansanella
Alina Sîrbu
Giulio Rossetti
ResearchOpen Access05 Sept 2023
Scientific Reports

Volume: 13, P: 1-15

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