This study shows that a non-clustered protocadherin, NFPC, is locally translated in retinal axons in response to Sema3A and demonstrates that NFPC-mediated homophilic adhesion helps guide retinal axons in the optic tract, thus revealing a new mechanism for axon guidance by linking a diffusible cue to adhesion-based navigation.
- Louis C Leung
- Vasja Urbančič
- Christine E Holt
