FOXO transcription factors confer stress resistance and longevity in several organisms. Ruvkun and colleagues demonstrate in Caenorhabditis elegans that DAF-16 (FOXO homologue) recruits the chromatin remodeller SWI/SNF to target genes. They show that SWI/SNF is required for DAF-16-mediated functions such as dauer formation, stress resistance and increasing longevity.
- Christian G. Riedel
- Robert H. Dowen
- Gary Ruvkun