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Showing 51–100 of 129 results

Advanced filters: Author: G. Simard Clear advanced filters

Long-term longitudinal analysis of 4,187 participants reveals insights into determinants of clonal hematopoiesis

Clonal hematopoiesis of indeterminate potential (CHIP) is linked to diverse aging-related diseases but the underlying factors driving its development are largely unknown. Here, longitudinal assessment of 4,187 participants over 21 years provides insights into cell-intrinsic and -extrinsic factors contributing to the development and progression of CHIP clones in older adults.

Md Mesbah Uddin
Seyedmohammad Saadatagah
Pradeep Natarajan
ResearchOpen Access09 Sept 2024
Nature Communications

Volume: 15, P: 1-14
Author Correction: Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

Kate Lawrenson
Siddhartha Kar
Simon A. Gayther
Amendments and CorrectionsOpen Access08 Sept 2025
Nature Communications

Volume: 16, P: 1-2
BRCA1 and BRCA2 mutations in Turkish breast/ovarian families and young breast cancer patients

H Yazici
O Bitisik
H Ozcelik
ResearchOpen Access22 Aug 2000
British Journal of Cancer

Volume: 83, P: 737-742
Significant and persistent impact of timber harvesting on soil microbial communities in Northern coniferous forests

Martin Hartmann
Charles G Howes
William W Mohn
Research02 Aug 2012
The ISME Journal

Volume: 6, P: 2199-2218
Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators

The structure of GlyRα3 in complex with a selective potentiator that decreases neuropathic pain in an animal model identifies a novel allosteric regulatory mechanism.

Xin Huang
Paul L Shaffer
Jacinthe Gingras
Research19 Dec 2016
Nature Structural & Molecular Biology

Volume: 24, P: 108-113
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk

Mammographic density is a strong risk factor for breast cancer. Here, the authors identify several new loci associated dense area, non-dense area and percent density, and highlight a shared genetic basis for mammographic density and breast cancer.

Sara Lindström
Deborah J. Thompson
Rulla M. Tamimi
Research24 Oct 2014
Nature Communications

Volume: 5, P: 1-8
Magnetic fields in galaxies and beyond

Ellen G. Zweibel
Carl Heiles
Reviews09 Jan 1997
Nature

Volume: 385, P: 131-136
Argonaute proteins: key players in RNA silencing

The family of Argonaute proteins has important roles in RNA-mediated gene silencing. Argonaute proteins form complexes with small non-coding RNAs such as small interfering RNAs and microRNAs, control protein synthesis and mRNA stability, and participate in the production of a new class of small RNAs, Piwi-interacting RNAs.

Gyorgy Hutvagner
Martin J. Simard
Reviews01 Jan 2008
Nature Reviews Molecular Cell Biology

Volume: 9, P: 22-32
Identification of six new susceptibility loci for invasive epithelial ovarian cancer

Georgia Chenevix-Trench and colleagues report meta-analyses of genome-wide association studies identifying six loci newly associated with epithelial ovarian cancer (EOC). They also test variants at the 12 known and 6 new EOC susceptibility loci for association in BRCA1 and BRCA2 mutation carriers.

Karoline B Kuchenbaecker
Susan J Ramus
Georgia Chenevix-Trench
Research12 Jan 2015
Nature Genetics

Volume: 47, P: 164-171
Prediction of maximal aerobic power from a submaximal exercise test performed by paraplegics on a wheelchair ergometer

G Paré
L Noreau
C Simard
Research01 Sept 1993
Spinal Cord

Volume: 31, P: 584-592
Distinct phenotype of CD4⁺ T cells driving celiac disease identified in multiple autoimmune conditions

Mass cytometry identifies a unique phenotype enriched in CD4⁺ T cells isolated from autoimmune disease patients.

Asbjørn Christophersen
Eivind G. Lund
Mark M. Davis
Research25 Mar 2019
Nature Medicine

Volume: 25, P: 734-737
Correction: Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

Maya Ghoussaini
Stacey L. Edwards
Alison M. Dunning
Amendments and Corrections10 Apr 2018
Nature Communications

Volume: 9, P: 1-2
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

Doug Easton and colleagues report the results of a large-scale genome-wide association study of breast cancer. They discover 15 new susceptibility loci and highlight likely target genes in several of the newly associated regions.

Kyriaki Michailidou
Jonathan Beesley
Douglas F Easton
Research09 Mar 2015
Nature Genetics

Volume: 47, P: 373-380
Machine learning-assisted quantitative metabolomics of West African patients with advanced breast cancer

Aboubacar Dit Tietie Bissan
Mathieu Michel
Pascal Reynier
ResearchOpen Access12 Aug 2025
Scientific Reports

Volume: 15, P: 1-13
Identification of a founder BRCA2 mutation in Sardinia

M Pisano
A Cossu
Francesco Tanda
ResearchOpen Access07 Jan 2000
British Journal of Cancer

Volume: 82, P: 553-559
Identification of a C/G polymorphism in the promoter region of the BRCA1 gene and its use as a marker for rapid detection of promoter deletions

A Catteau
C-F Xu
E Solomon
ResearchOpen Access29 Jan 1999
British Journal of Cancer

Volume: 79, P: 759-763
EVIDENCES OF OVARIAN HYPERFUNCTION IN ADDLESCENT GIRLS WITH INSULIN DEPENDENT DIABETES MELLITUS (IDDM) AND MENSTRUAL DISORDERS

R Virdis
M Vanelli
G Giovannelli
Research01 May 1993
Pediatric Research

Volume: 33, P: S20
Polygenic risk modeling for prediction of epithelial ovarian cancer risk

Eileen O. Dareng
Jonathan P. Tyrer
Paul D. P. Pharoah
ResearchOpen Access14 Jan 2022
European Journal of Human Genetics

Volume: 30, P: 349-362
SMN transcript levels in leukocytes of SMA patients determined by absolute real-time PCR

Francesco Danilo Tiziano
Anna Maria Pinto
Christina Brahe
Research15 Jul 2009
European Journal of Human Genetics

Volume: 18, P: 52-58
Representing the function and sensitivity of coastal interfaces in Earth system models

Coastal systems are hotspots of ecological, geochemical and economic activity, yet their dynamics are not accurately represented in global models. In this Review, Ward and colleagues assess the current state of coastal science and recommend approaches for including the coastal interface in predictive models.

Nicholas D. Ward
J. Patrick Megonigal
Lisamarie Windham-Myers
ReviewsOpen Access18 May 2020
Nature Communications

Volume: 11, P: 1-14
A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

Fergus Couch and colleagues report a genome-wide association study for modifiers of breast cancer susceptibility in BRCA1 mutation carriers. They identify a locus at 19p13 associated with breast cancer risk in BRCA1 mutation carriers, and further replication studies identify this locus as associated with estrogen receptor–negative breast cancer in the general population.

Antonis C Antoniou
Xianshu Wang
Fergus J Couch
Research19 Sept 2010
Nature Genetics

Volume: 42, P: 885-892
Characteristics of small breast and/or ovarian cancer families with germline mutations in BRCA1 and BRCA2

M J L Ligtenberg
F B L Hogervorst
L J Van’t Veer
ResearchOpen Access26 Feb 1999
British Journal of Cancer

Volume: 79, P: 1475-1478
Identification of Rad51 alteration in patients with bilateral breast cancer

M. Kato
K. Yano
Y. Miki
Research01 May 2000
Journal of Human Genetics

Volume: 45, P: 133-137
Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV

Alexander G. Bick
Konstantin Popadin
S. Yerly
ResearchOpen Access12 Jan 2022
Scientific Reports

Volume: 12, P: 1-7
Enhanced green fluorescent protein fusion proteins of herpes simplex virus type 1 thymidine kinase and cytochrome P450 4B1: Applications for prodrug-activating gene therapy

Sabine Steffens
Susanne Frank
Christof M Kramm
Research15 Jun 2000
Cancer Gene Therapy

Volume: 7, P: 806-812
Correlation of SMNt and SMNc gene copy number with age of onset and survival in spinal muscular atrophy

Joanne E Taylor
Neil H Thomas
Christopher G Mathew
Research18 Nov 1998
European Journal of Human Genetics

Volume: 6, P: 467-474
Identification of common variants associated with human hippocampal and intracranial volumes

Paul Thompson and colleagues report a genome-wide association study for hippocampal, intracranial and total brain volume. They identify a locus at 12q24 associated with hippocampal volume and a locus at 12q14 associated with intracranial volume.

Jason L Stein
Sarah E Medland
Paul M Thompson
Research15 Apr 2012
Nature Genetics

Volume: 44, P: 552-561
Rare germline copy number variants (CNVs) and breast cancer risk

Dennis et al. investigate potential breast cancer associations with rare germline copy number variants (CNVs) by conducting a genome-wide analysis in a large breast cancer case-control dataset. The authors detected associations with exonic deletions in established breast cancer susceptibility genes and suggestive associations for a number of non-coding CNVs.

Joe Dennis
Jonathan P. Tyrer
Douglas F. Easton
ResearchOpen Access18 Jan 2022
Communications Biology

Volume: 5, P: 1-15
Ovarian cysts in women receiving tamoxifen for breast cancer

M J E Mourits
E G E de Vries
A G J van der Zee
ResearchOpen Access12 Mar 1999
British Journal of Cancer

Volume: 79, P: 1761-1764
Publisher Correction: Shared heritability and functional enrichment across six solid cancers

Xia Jiang
Hilary K. Finucane
Sara Lindström
Amendments and CorrectionsOpen Access23 Sept 2019
Nature Communications

Volume: 10, P: 1-8
Two truncating variants in FANCC and breast cancer risk

Thilo Dörk
Paolo Peterlongo
Douglas F. Easton
ResearchOpen Access29 Aug 2019
Scientific Reports

Volume: 9, P: 1-14
A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns

Pancreatic cancer is not caused by a specific series of genetic alterations that occur sequentially but by one, or few, catastrophic events that result in simultaneous oncogenic genetic rearrangements, giving rise to highly aggressive tumours.

Faiyaz Notta
Michelle Chan-Seng-Yue
Steven Gallinger
Research12 Oct 2016
Nature

Volume: 538, P: 378-382
Properties and Crystallization of Maleated Polypropylene/Graphite Flake Nanocomposites

Danny J Y S Pagé
Thottupurathu G Gopakumar
Reviews28 Jul 2006
Polymer Journal

Volume: 38, P: 920-929
Induction of sensitivity to NK-mediated cytotoxicity by TNF-α treatment: possible role of ICAM-3 and CD44

G Maki
G Krystal
H-G Klingemann
Research29 Oct 1998
Leukemia

Volume: 12, P: 1565-1572
Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Juliette Coignard
Michael Lush
Antonis C. Antoniou
Amendments and CorrectionsOpen Access14 May 2021
Nature Communications

Volume: 12, P: 1-2
MicroRNAs and cancer: issue summary

G Hutvagner
Reviews09 Oct 2006
Oncogene

Volume: 25, P: 6154-6155
Hydro-climatic changes of wetlandscapes across the world

I. Åhlén
G. Vigouroux
J. Jarsjö
ResearchOpen Access02 Feb 2021
Scientific Reports

Volume: 11, P: 1-11
Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers

Frank Qian
Matti A. Rookus
Dezheng Huo
ResearchOpen Access19 Jun 2019
British Journal of Cancer

Volume: 121, P: 180-192
Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Hanla A. Park
Sonja Neumeyer
Jenny Chang-Claude
ResearchOpen Access02 Aug 2021
British Journal of Cancer

Volume: 125, P: 1135-1145
Strong reduction of AGO2 expression in melanoma and cellular consequences

D Völler
J Reinders
A-K Bosserhoff
ResearchOpen Access29 Oct 2013
British Journal of Cancer

Volume: 109, P: 3116-3124
DarkCideS 1.0, a global database for bats in karsts and caves

Krizler C. Tanalgo
John Aries G. Tabora
Alice Catherine Hughes
ResearchOpen Access05 Apr 2022
Scientific Data

Volume: 9, P: 1-12
Tissue-type plasminogen activator has antiangiogenic properties without effect on tumor growth in a rat C6 glioma model

F Solly
R Fish
G Pernod
Research06 Jun 2008
Cancer Gene Therapy

Volume: 15, P: 685-692
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli
Massimo Bogliolo
Paolo Peterlongo
ResearchOpen Access01 Nov 2019
npj Breast Cancer

Volume: 5, P: 1-14
Effects of changes in water compartments on physiology and metabolism

P Ritz
A Salle
Y Malthiery
Research18 Dec 2003
European Journal of Clinical Nutrition

Volume: 57, P: S2-S5
Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk

Jingjing Liu
Wendy J. C. Prager - van der Smissen
Antoinette Hollestelle
ResearchOpen Access16 Jun 2020
Scientific Reports

Volume: 10, P: 1-14
Evaluation of the association of heterozygous germline variants in NTHL1 with breast cancer predisposition: an international multi-center study of 47,180 subjects

Na Li
Magnus Zethoven
Ian G. Campbell
ResearchOpen Access12 May 2021
npj Breast Cancer

Volume: 7, P: 1-12
Ovarian cancer pathology characteristics as predictors of variant pathogenicity in BRCA1 and BRCA2

Denise G. O’Mahony
Susan J. Ramus
Elizabeth Santana dos Santos
ResearchOpen Access19 Apr 2023
British Journal of Cancer

Volume: 128, P: 2283-2294
Genome-wide association study of germline variants and breast cancer-specific mortality

Maria Escala-Garcia
Qi Guo
Marjanka K. Schmidt
ResearchOpen Access21 Feb 2019
British Journal of Cancer

Volume: 120, P: 647-657
A new species in the major malaria vector complex sheds light on reticulated species evolution

Maite G. Barrón
Christophe Paupy
Diego Ayala
ResearchOpen Access14 Oct 2019
Scientific Reports

Volume: 9, P: 1-13
CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Nichola Johnson
Sarah Maguire
Olivia Fletcher
ResearchOpen Access26 Jan 2021
British Journal of Cancer

Volume: 124, P: 842-854

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