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Showing 1–3 of 3 results
Advanced filters: Author: Gable M. Wadsworth Clear advanced filters

  • The physicochemical driving forces of protein-free, RNA-driven phase transitions were previously unclear, but it is now shown that RNAs undergo entropically driven liquid–liquid phase separation upon heating in the presence of magnesium ions. In the condensed phase, RNAs can undergo an enthalpically favourable percolation transition that leads to arrested condensates.

    • Gable M. Wadsworth
    • Walter J. Zahurancik
    • Priya R. Banerjee
    Research
    Nature Chemistry
    Volume: 15, P: 1693-1704

  • Pathological aggregation of repeat-expanded RNA is implicated in neurodegeneration. Now results demonstrate that biomolecular condensates can promote irreversible clustering of GC-rich repeat RNAs facilitated by RNA percolation, leading to an emergent liquid-to-solid phase transition. This aberrant RNA self-assembly can be counteracted by RNA-binding proteins and anti-sense oligonucleotides that enforce heterotypic buffering.

    • Tharun Selvam Mahendran
    • Gable M. Wadsworth
    • Priya R. Banerjee
    Research
    Nature Chemistry
    Volume: 17, P: 1236-1246

  • Pop1 and 6 are subunits of RNase P and RNase MRP, which process ribosomal and tRNAs. The authors show that when Pop1 and 6 are impaired, the telomerase subunit Est1 binds telomerase RNA at normal levels, but the binding is unstable. As a result, nuclear import of the telomerase holoenzyme is inhibited.

    • P. Daniela Garcia
    • Robert W. Leach
    • Virginia A. Zakian
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-19