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Showing 1–22 of 22 results
Advanced filters: Author: Gabriel D Victora Clear advanced filters
  • Serum antibody responses to sequential homologous booster vaccines derive overwhelmingly from primary cohort B cells at the expense of de novo responses; this ‘primary addiction’ can be overcome by boosting with variant antigens.

    • Ariën Schiepers
    • Marije F. L. van ’t Wout
    • Gabriel D. Victora
    Research
    Nature
    Volume: 615, P: 482-489
  • Antibody selection and maturation within B cells found in gut-associated germinal centres is stimulated by the gut microbiota, to a degree that depends on the presence and composition of the microbes.

    • Carla R. Nowosad
    • Luka Mesin
    • Gabriel D. Victora
    Research
    Nature
    Volume: 588, P: 321-326
  • Three separate rounds of serological surveys in the state of Rio Grande do Sul in Brazil from mid-April to mid-May 2020 show an increase in antibodies specific for SARS-CoV-2 over time.

    • Mariângela F. Silveira
    • Aluísio J. D. Barros
    • Cesar G. Victora
    Research
    Nature Medicine
    Volume: 26, P: 1196-1199
  • A paper reports the development of a universal tool for studying cellular interactions in biological systems, and demonstrates its coupling with single-cell transcriptomics methods to provide insights into the biology of the interactions.

    • Sandra Nakandakari-Higa
    • Sarah Walker
    • Gabriel D. Victora
    Research
    Nature
    Volume: 627, P: 399-406
  • Innate lymphoid cells, marginal reticular cells and B cell–helper neutrophils interact to promote antibody secretion by B cells in the marginal zone of the spleen in humans and mice.

    • Gabriel D Victora
    News & Views
    Nature Immunology
    Volume: 15, P: 313-314
  • Functional genomics and lipidomic analyses reveal that sphingolipid synthesis is required for tumour immune evasion and tumour growth in vivo, mediated in part by the impact of glycosphingolipid synthesis on cell surface expression of IFNγ receptors.

    • Mariluz Soula
    • Gokhan Unlu
    • Kıvanç Birsoy
    Research
    Nature
    Volume: 633, P: 451-458
  • A suite of human monoclonal antibodies block infection by all human ACE2 binding sarbecoviruses, including severe acute respiratory syndrome coronavirus 2 variants, at subnanomolar concentrations in cell culture and protect mice against severe acute respiratory syndrome coronavirus 2 infection.

    • Fengwen Zhang
    • Jesse Jenkins
    • Paul D. Bieniasz
    ResearchOpen Access
    Nature Microbiology
    Volume: 8, P: 1051-1063
  • Highly proliferative cells have classically been thought to rely on anaerobic glycolysis for fuel. Weisel et al. show that germinal center B cells break this rule, as they primarily utilize fatty acid oxidation to meet their metabolic demands.

    • Juhee Pae
    • Gabriel D. Victora
    News & Views
    Nature Immunology
    Volume: 21, P: 249-250
  • Some follicular B cell lymphomas harbour activating mutations in RRAGC, activator of the nutrient sensor mTORC1. Here the authors show that these mutations confer insensitivity to nutrient deprivation and synergize with paracrine cues from the supportive T cell microenvironment to accelerate lymphomagenesis, but impose vulnerability to inhibition of mTORC1.

    • Ana Ortega-Molina
    • Nerea Deleyto-Seldas
    • Alejo Efeyan
    Research
    Nature Metabolism
    Volume: 1, P: 775-789
  • The authors pooled resources to identify best practices and develop a new standardized protocol for estimating functional connectivity in rats with magnetic resonance imaging.

    • Joanes Grandjean
    • Gabriel Desrosiers-Gregoire
    • Andreas Hess
    Research
    Nature Neuroscience
    Volume: 26, P: 673-681
  • Emerging evidence shows that boosting with updated mRNA vaccines that target SARS-CoV-2 variants stimulates better neutralizing antibody responses than homologous boosters.

    • Deepta Bhattacharya
    • Gabriel D. Victora
    News & Views
    Nature Medicine
    Volume: 28, P: 2257-2258
  • Human follicular lymphomas arise from germinal center B cells. Milpied and colleagues use single-cell transcriptomic analysis to show that follicular lymphoma cells lose synchronized gene-expression patterns that characterize normal germinal center B cells.

    • Pierre Milpied
    • Iñaki Cervera-Marzal
    • Bertrand Nadel
    Research
    Nature Immunology
    Volume: 19, P: 1013-1024
  • Abnormal behavioural phenotypes and synapse loss in the brain of lupus-prone mice are prevented by blocking type I interferon signalling, which is further shown to stimulate microglial phagocytosis of neuronal material in the brains of these mice.

    • Allison R. Bialas
    • Jessy Presumey
    • Michael C. Carroll
    Research
    Nature
    Volume: 546, P: 539-543