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Showing 1–1 of 1 results
Advanced filters: Author: Gabriel E. Valdebenito Clear advanced filters
  • Heteroplasmic mtDNA mutations cause disease in humans. Here, Chung et al find the PI3K-Akt-mTORC1 pathway constitutively activated in cells with the heteroplasmic m.3243 A > G mutation, and inhibition of the pathway cell autonomously reduces mutant mtDNA load and rescues mitochondrial bioenergetics.

    • Chih-Yao Chung
    • Kritarth Singh
    • Michael R. Duchen
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16