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Showing 1–4 of 4 results

Advanced filters: Author: Gabriel L. McKinsey Clear advanced filters

Dynamic fibroblast–immune interactions shape recovery after brain injury

Spatial transcriptomic studies and lineage tracing reveal that, after brain injury, transient profibrotic fibroblasts develop from existing brain fibroblasts, infiltrate lesions, regulate the local immune response and lead to beneficial scar tissue formation.

Nathan A. Ewing-Crystal
Nicholas M. Mroz
Ari B. Molofsky
ResearchOpen Access03 Sept 2025
Nature

P: 1-11
Radial glia integrin avb8 regulates cell autonomous microglial TGFβ1 signaling that is necessary for microglial identity

Microglial states are dynamically regulated during development and disease. Here, the authors show that these changes are mediated by cell autonomous TGF-β signaling in microglia, which is developmentally regulated by ITGB8 in radial glia.

Gabriel L. McKinsey
Nicolas Santander
Thomas D. Arnold
ResearchOpen Access22 Mar 2025
Nature Communications

Volume: 16, P: 1-21
APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

The APOE4 allele is a major genetic risk factor for the development of late-onset Alzheimer’s disease (AD). In this manuscript, Butovsky and colleagues suggest that APOE4 impairs the microglial response in AD by inducing TGFβ-mediated checkpoints.

Zhuoran Yin
Neta Rosenzweig
Oleg Butovsky
Research25 Sept 2023
Nature Immunology

Volume: 24, P: 1839-1853
Optimization and validation of the international metabolic prognostic index for CD19 CAR-T in large B-cell lymphoma

Michael Winkelmann
Sandeep S. Raj
Kai Rejeski
ResearchOpen Access26 Aug 2025
Blood Cancer Journal

Volume: 15, P: 1-10