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Showing 1–5 of 5 results
Advanced filters: Author: Gabriel Moreno-Hagelsieb Clear advanced filters

  • An array-based high-throughput approach termed Escherichia coli synthetic genetic array, or eSGA, now allows comprehensive genetic interaction screens in bacteria. The method makes use of bacterial conjugation and robotic technology to generate double mutants on a genome-wide scale. In this issue, another paper presents GIANT-coli, a very similar approach.

    • Gareth Butland
    • Mohan Babu
    • Andrew Emili
    Research
    Nature Methods
    Volume: 5, P: 789-795

  • Phosphonate modifications can be present on microbial cell surfaces. Here the authors perform bioinformatics analyses and observe a widespread occurrence of nucleotidyltransferase-encoding genes in bacterial phosphonate biosynthesis and functionally characterize two of the identified phosphonate specific cytidylyltransferases (PntCs) and determine the crystal structure of T. denticola PntC.

    • Kyle Rice
    • Kissa Batul
    • Geoff P. Horsman
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Kenneth Croitoru, Andrew Paterson and colleagues perform genome-wide association analysis for gut microbiome composition. They identify 58 SNPs significantly associated with relative abundance of 33 taxa and replicate 4 of the associations in an independent cohort, providing further evidence that host genetics can influence the gut microbiota.

    • Williams Turpin
    • Osvaldo Espin-Garcia
    • Kenneth Croitoru
    Research
    Nature Genetics
    Volume: 48, P: 1413-1417