AMP-activated protein kinase is a central regulator of energy homeostasis in mammals, and the Saccharomyces cerevisiae homologue SNF1 is essential for responses to nutrient starvation. This structure reveals features such as the ligand-binding site in the γ-subunit, the carbohydrate-binding domain in the β-subunit and a regulatory sequence in the α-subunit.
- Gabriele A. Amodeo
- Michael J. Rudolph
- Liang Tong
