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Glucocorticoid receptor antagonization propels endogenous cardiomyocyte proliferation and cardiac regeneration

Pianca and Sacchi et al. unveil an important role for glucocorticoids and their receptor (GR) in cardiomyocyte cytoarchitectural/metabolic maturation, cell cycle exit and loss of regenerative ability, and they propose GR antagonization as a strategy for heart regeneration.

Nicola Pianca
Francesca Sacchi
Gabriele D’Uva
Research23 Jun 2022
Nature Cardiovascular Research

Volume: 1, P: 617-633
BMP signaling promotes zebrafish heart regeneration via alleviation of replication stress

Zebrafish show robust heart regeneration after injury. Here they show that zebrafish cardiomyocytes experience replication stress, which BMP signaling alleviates via a conserved mechanism of replication fork restart, suggesting a potential for anti-aging and regenerative therapies.

Mohankrishna Dalvoy Vasudevarao
Denise Posadas Pena
Gilbert Weidinger
ResearchOpen Access17 Feb 2025
Nature Communications

Volume: 16, P: 1-20
A tunable gene therapy for heart regeneration

AAV-based gene therapies hold promise for treating disease, but their long-lasting gene expression limits their use in regenerative medicine. A study now presents DreAM, a drug-inducible AAV system that enables tunable tissue-specific gene activation via the splicing modulator risdiplam, and its potential application in myocardial infarction.

Gabriele D’Uva
News & Views13 Jun 2025
Nature Cardiovascular Research

Volume: 4, P: 794-796
CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions

The chemokine CXCL12 is essential for hematopoietic stem cell function. Lapidot and colleagues report that secretion of CXCL12 from bone marrow stromal cells is a cell contact–dependent event, mediated by connexin-43 and connexin-45 gap junctions.

Amir Schajnovitz
Tomer Itkin
Tsvee Lapidot
Research27 Mar 2011
Nature Immunology

Volume: 12, P: 391-398
Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment

Glucocorticoids are released in a diurnal pattern. Here, the authors show that EGF receptor (EGFR) signalling is negatively regulated by glucocorticoids, and that EGFR inhibitor has stronger antitumour effects when administered during the resting phase, when glucocorticoids are low, offering potential optimization of cancer therapy regimens.

Mattia Lauriola
Yehoshua Enuka
Yosef Yarden
ResearchOpen Access03 Oct 2014
Nature Communications

Volume: 5, P: 1-13
ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation

Tzahor and colleagues show that ErbB2 signalling is required for cardiomyocyte proliferation in fetal and postnatal mouse hearts, and that its activation in adult hearts promotes cardiomyocyte proliferation and regeneration following myocardial ischaemic injury.

Gabriele D’Uva
Alla Aharonov
Eldad Tzahor
Research06 Apr 2015
Nature Cell Biology

Volume: 17, P: 627-638
Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow

Hematopoietic stem cells must be shielded from toxic and inflammatory insults to ensure lifelong blood cell production. Lapidot and colleagues identify a rare bone marrow macrophage population that protects hematopoietic stem cells.

Aya Ludin
Tomer Itkin
Tsvee Lapidot
Research16 Sept 2012
Nature Immunology

Volume: 13, P: 1072-1082
Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation

A new model of cardiac trabeculation in mice is presented in which NOTCH1 and NRG1 have opposing roles in extracellular matrix degradation and synthesis that are essential for defining trabecular architecture.

Gonzalo del Monte-Nieto
Mirana Ramialison
Richard P. Harvey
Research09 May 2018
Nature

Volume: 557, P: 439-445
Aberrant MET activation impairs perinuclear actin cap organization with YAP1 cytosolic relocation

Analysis of actin dynamics in cancer reveals that MET hyperactivation drives perinuclear actin cap disruption by YAP1 inhibition, inducing nuclear expansion, meandering cell motility and collapse of the apical microvilli into actin-rich patches.

Michela Sgarzi
Martina Mazzeschi
Mattia Lauriola
ResearchOpen Access14 Oct 2023
Communications Biology

Volume: 6, P: 1-16

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