The E2-like enzyme Atg3 conjugates phosphatidylethanolamine (PE) to Atg8 to facilitate its membrane association and promote autophagosome maturation. Melia and colleagues report that Atg3 preferentially associates in vitro with highly curved, PE-enriched membranes, such as the isolation membrane of a nascent autophagosome, thus ensuring access to a local supply of PE.
- Sangeeta Nath
- Julia Dancourt
- Thomas J. Melia
