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Showing 1–3 of 3 results
Advanced filters: Author: Gabrielle Kardon Clear advanced filters

  • Gabrielle Kardon and colleagues present a detailed study of diaphragm development in mice. They show that migration of connective tissue fibroblasts derived from the pleuroperitoneal folds controls diaphragm morphogenesis and that mosaic ablation of Gata4 in this cell population results in defects resembling human congenital diaphragmatic hernias.

    • Allyson J Merrell
    • Benjamin J Ellis
    • Gabrielle Kardon
    Research
    Nature Genetics
    Volume: 47, P: 496-504

  • Duchenne muscular dystrophy (DMD) is a devastating X-linked disease that is characterized by progressive muscle degeneration and caused by mutations in dystrophin. Dystrophin is critical for myofiber structural integrity, but a new study reveals an additional important role for this protein in muscle stem cells.

    • Alexandra C Keefe
    • Gabrielle Kardon
    News & Views
    Nature Medicine
    Volume: 21, P: 1391-1393

  • Skeletal muscle satellite cells are muscle stem cells believed to contribute only to regenerating myofibres. Here Keefe et al. show that in adult sedentary mice satellite cells continue to fuse with uninjured myofibres, but they are not globally required for the maintenance of aging muscles.

    • Alexandra C. Keefe
    • Jennifer A. Lawson
    • Gabrielle Kardon
    Research
    Nature Communications
    Volume: 6, P: 1-11