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Showing 1–3 of 3 results
Advanced filters: Author: Galit Lev-Maor Clear advanced filters

  • We know that most splicing reactions take place co-transcriptionally, but how the transcription machinery facilitate splicing of introns is unknown. Here the authors show that the 5′ splice site remains associated with the transcription machinery during intron synthesis through U1 snRNP, providing a basis for the rapid splicing reaction of introns.

    • Yodfat Leader
    • Galit Lev Maor
    • Gil Ast
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Long primary transcripts of microRNAs are co-transcriptionally cleaved by the enzyme Drosha. Here the authors suggest that DNA methylation in miRNA loci in mammalian cells increases Drosha binding, slowing RNA polymerase II elongation to enhance miRNA biogenesis.

    • Ohad Glaich
    • Shivang Parikh
    • Carmit Levy
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • The detailed characterization of the genomes and transcriptomes of diverse species has enabled advances in our understanding of how alternative splicing and alternatively spliced genes have evolved. Evolutionary studies are also contributing insights into how exons are defined and how splicing is regulated.

    • Hadas Keren
    • Galit Lev-Maor
    • Gil Ast
    Reviews
    Nature Reviews Genetics
    Volume: 11, P: 345-355