Tumor suppressor protein p53 interacts with and is acetylated by PHF20, but the consequences of this association were not clear. Now PHF20 is shown to be a direct regulator of p53, with its Tudor domain recognizing p53 modified with dimethyl groups at Lys370 or Lys382. This association promotes p53's stabilization and activation during the DNA-damage response, by inhibiting the association of Mdm2 with p53.
- Gaofeng Cui
- Sungman Park
- Georges Mer
