Aza-azetidines, indole-azetidines, and spirocyclic azetidines with tertiary or quaternary C3 carbons make structural and/or functional parts of various important drug molecules. Here, the authors report HFIP-assisted, Brønsted acid-catalyzed, strain-release-driven ring openings of ABB to access aza-azetidines, indole-azetidines, and spirocyclic azetidines with quaternary C3-carbons in good yield.
- Subrata Hazra
- Arushi Tyagi
- Santanu Panda
