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Showing 1–8 of 8 results
Advanced filters: Author: Gary E. Landreth Clear advanced filters

  • Activation of the ligand-inducible transcription factor peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to suppress inflammation in peripheral macrophages and in models of human autoimmune disease. As Heneka et al. discuss in this Review, PPARγ is now being investigated as a potential therapeutic target in CNS disorders with an inflammatory component, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and multiple sclerosis.

    • Michael T Heneka
    • Gary E Landreth
    • Michael Hüll
    Reviews
    Nature Clinical Practice Neurology
    Volume: 3, P: 496-504

  • A deep learning approach bypasses iterative trials associated with sensorless adaptive optics to compensate for wavefront deformations when imaging biological specimens, enabling improved deep tissue localization microscopy.

    • Peiyi Zhang
    • Donghan Ma
    • Fang Huang
    ResearchOpen Access
    Nature Methods
    Volume: 20, P: 1748-1758

  • Martinez et al. identified the protein interactome of the tau seed responsible for propagation. The authors found how the presynaptic protein Bassoon interacts with the tau seed enhancing its stability and subsequently tau toxicity and spreading.

    • Pablo Martinez
    • Henika Patel
    • Cristian A. Lasagna-Reeves
    ResearchOpen Access
    Nature Neuroscience
    Volume: 25, P: 1597-1607

  • This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet and infections, and host-intrinsic factors, such as the activity of microglial cells and other immune, vascular and neuronal cell populations, on disease development. They also highlight emerging drugs that target this inflammatory component for therapy of Alzheimer disease.

    • Michael T. Heneka
    • Wiesje M. van der Flier
    • Sean-Patrick Riechers
    Reviews
    Nature Reviews Immunology
    Volume: 25, P: 321-352