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Showing 1–5 of 5 results
Advanced filters: Author: Gaurav Tuli Clear advanced filters

  • Varrelman et al. use participatory surveillance data to develop a method to identify changes in vaccine effectiveness and disease symptomatology. Using data from the COVID-19 pandemic, they identify a reduction in vaccine effectiveness during Omicron dominated waves of infections, and a shift towards upper respiratory type symptoms.

    • Tanner J. Varrelman
    • Benjamin Rader
    • John S. Brownstein
    ResearchOpen Access
    Communications Medicine
    Volume: 4, P: 1-6

  • SARS-CoV-2 uses the host endolysosomal system for replication and egress. Here the authors show that SARS-CoV-2 virulence factor ORF3a localizes to the late endocytic compartments of the host cell to disrupt Rab7 GTP to GDP cycling and block lysosome function in cargo degradation, while activated Rab7 promotes virus replication.

    • Kshitiz Walia
    • Abhishek Sharma
    • Amit Tuli
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-24

  • Lysosomes move along microtubule tracks, and Arl8b is known to stimulate their anterograde transport. Here, the authors identified RUFY3 as an Arl8b effector that interacts with dynein-dynactin to drive retrograde transport and perinuclear lysosome positioning.

    • Gaurav Kumar
    • Prateek Chawla
    • Amit Tuli
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • Using large-scale data, Kraemer et al. find that human mobility patterns vary across the globe and in scale by environmental and sociodemographic contexts. There are tenfold differences in mobility patterns depending on the countries’ economic development.

    • Moritz U. G. Kraemer
    • Adam Sadilek
    • John S. Brownstein
    Research
    Nature Human Behaviour
    Volume: 4, P: 800-810