Starvation triggers autophagy by inhibiting mTOR signalling. Here, Moreau et al.identify an alternative, transcriptional activation pathway: starvation-induced JNK signalling upregulates Annexin A2 transcription, which in turn enhances actin-dependent transport of Atg9 vesicles from endosomes to autophagosomes.
- Kevin Moreau
- Ghita Ghislat
- David C. Rubinsztein
