Nature Search

Global, regional and national burden of dietary iron deficiency from 1990 to 2021: a Global Burden of Disease study

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Sooji Lee
Yejun Son
Nicholas. J. Kassebaum
Research22 Apr 2025
Nature Medicine

Volume: 31, P: 1809-1829
Multi-omics in nasal epithelium reveals three axes of dysregulation for asthma risk in the African Diaspora populations

Here, the authors suggest that molecular dysregulation on three axes may play a critical role in asthma within the African Diaspora. RNASeq and DNA methylation data are generated from nasal epithelium including cases and controls from seven different geographic sites.

Brooke Szczesny
Meher Preethi Boorgula
Rasika A. Mathias
ResearchOpen Access28 May 2024
Nature Communications

Volume: 15, P: 1-12
A spatial architecture-embedding HLA signature to predict clinical response to immunotherapy in renal cell carcinoma

Multiomics and spatial mapping of tumor samples derived from a real-world cohort of patients with advanced renal cell carcinoma, as well as integration of transcriptomics and human leukocyte antigen genotyping data, provides a machine learning-derived signature of response to immune checkpoint blockade.

Lisa Kinget
Stefan Naulaerts
Abhishek D. Garg
Research21 May 2024
Nature Medicine

Volume: 30, P: 1667-1679
Author Correction: A spatial architecture-embedding HLA signature to predict clinical response to immunotherapy in renal cell carcinoma

Lisa Kinget
Stefan Naulaerts
Abhishek D. Garg
Amendments and Corrections15 Jul 2024
Nature Medicine

Volume: 30, P: 2375-2376
Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping

Chromatin looping plays an important role in gene regulation and the ability to manipulate loops would aid in understanding how this occurs. Here the authors present CLOuD9, a system that uses dimerized Cas9 complexes to selectively and reversibly establish chromatin loops.

Stefanie L. Morgan
Natasha C. Mariano
Kevin C. Wang
ResearchOpen Access13 Jul 2017
Nature Communications

Volume: 8, P: 1-9
AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma

Basal cell carcinoma (BCC) cells with increased nuclear myocardin-related transcription factor (nMRTF) levels are resistant to Smoothened inhibitors, however how MRTF activity is regulated is still elusive. Here, the authors identify a LYPD3+/TACSTD2+/LY6D+ BCC subpopulation of resistant BCC cells where AP-1 and TGFß drive nMRTF activation and amplify noncanonical Gli1 activity

Catherine D. Yao
Daniel Haensel
Anthony E. Oro
ResearchOpen Access08 Oct 2020
Nature Communications

Volume: 11, P: 1-17
Honey bee Royalactin unlocks conserved pluripotency pathway in mammals

Royal jelly is the queen-maker for the honey bee that also has effects on longevity, fertility, and regeneration in mammals. Here the authors provide evidence that its major protein component Royalactin, and the mammalian structural analog Regina, maintain pluripotency in mouse ESCs by activating a ground-state pluripotency-like gene network.

Derrick C. Wan
Stefanie L. Morgan
Kevin C. Wang
ResearchOpen Access04 Dec 2018
Nature Communications

Volume: 9, P: 1-9
Discovering geroprotectors through the explainable artificial intelligence-based platform AgeXtend

Arora et al. present AgeXtend, an explainable artificial intelligence-based platform that leverages bioactivity data to predict geroprotectors. They validate potential geroprotectors identified using this platform in yeast, worm and senescence assays.

Sakshi Arora
Aayushi Mittal
Gaurav Ahuja
Research03 Dec 2024
Nature Aging

Volume: 5, P: 144-161
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell carcinomas

A large proportion of basal cell carcinomas develop resistance independently of the canonical mutations in genes encoding hedgehog pathway components. An unbiased analysis investigating alternative pathways of resistance uncovers the role of cytoskeletal signaling in driving noncanonical activation of hedgehog signaling through nuclear translocation of SRF and MKL1. These results advance understanding of the mechanisms underlying drug resistance and provide new actionable insights for clinical translation.

Ramon J Whitson
Alex Lee
Anthony E Oro
Research05 Feb 2018
Nature Medicine

Volume: 24, P: 271-281
Impact of carbon nanodot uptake on complex impedance charge transport and energy storage mechanism in aloe vera leaves

Kajal Gautam
Mohit Bhatt
Anil Kumar Sinha
ResearchOpen Access03 Apr 2025
Scientific Reports

Volume: 15, P: 1-17
Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment

Retinoic acid and BMP4 signaling, together with p63, contribute to dynamic long-range chromatin interactions during keratinocyte differentiation. TP63 decreases chromatin accessibility and promotes H3K27me3 accumulation at enhancers.

Jillian M. Pattison
Sandra P. Melo
Anthony E. Oro
Research05 Nov 2018
Nature Genetics

Volume: 50, P: 1658-1665
Characterization and evaluation of mycosterol secreted from endophytic strain of Gymnema sylvestre for inhibition of α-glucosidase activity

Amit Ranjan
Rajesh Kumar Singh
Santosh Kumar Singh
ResearchOpen Access21 Nov 2019
Scientific Reports

Volume: 9, P: 1-13
Development of Novel Triazolo-Thiadiazoles from Heterogeneous “Green” Catalysis as Protein Tyrosine Phosphatase 1B Inhibitors

C. P. Baburajeev
Chakrabhavi Dhananjaya Mohan
Kanchugarakoppal S. Rangappa
ResearchOpen Access21 Sept 2015
Scientific Reports

Volume: 5, P: 1-11

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Global, regional and national burden of dietary iron deficiency from 1990 to 2021: a Global Burden of Disease study

Multi-omics in nasal epithelium reveals three axes of dysregulation for asthma risk in the African Diaspora populations

A spatial architecture-embedding HLA signature to predict clinical response to immunotherapy in renal cell carcinoma

Author Correction: A spatial architecture-embedding HLA signature to predict clinical response to immunotherapy in renal cell carcinoma

Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping

AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma

Honey bee Royalactin unlocks conserved pluripotency pathway in mammals

Discovering geroprotectors through the explainable artificial intelligence-based platform AgeXtend

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell carcinomas

Impact of carbon nanodot uptake on complex impedance charge transport and energy storage mechanism in aloe vera leaves

Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment

Characterization and evaluation of mycosterol secreted from endophytic strain of Gymnema sylvestre for inhibition of α-glucosidase activity

Development of Novel Triazolo-Thiadiazoles from Heterogeneous “Green” Catalysis as Protein Tyrosine Phosphatase 1B Inhibitors

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