Nature Search

Engraftment of gene–modified umbilical cord blood cells in neonates with adenosine deaminase deficiency

Donald B. Kohn
Kenneth I. Weinberg
Robertson Parkman
Research01 Oct 1995
Nature Medicine

Volume: 1, P: 1017-1023
T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34⁺ cells in ADA-deficient SCID neonates

Donald B. Kohn
Michal S. Hershfield
Robertson Parkman
Research01 Jul 1998
Nature Medicine

Volume: 4, P: 775-780
Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin

'Lymphoid priming' in human bone marrow is traditionally thought to begin with the expression of CD10 on CD34⁺ progenitors. Crooks and colleagues now demonstrate lymphoid priming in a subset of CD10^–CD34⁺ progenitors that are CD62L^hi.

Lisa A Kohn
Qian-Lin Hao
Gay M Crooks
Research02 Sept 2012
Nature Immunology

Volume: 13, P: 963-971
Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages

Long non-coding RNAs contribute to the regulation of gene expression. Crooks and colleagues profile the long non-coding RNA transcriptome during the specification and development of human lymphocytes.

David Casero
Salemiz Sandoval
Gay M Crooks
Research01 Dec 2015
Nature Immunology

Volume: 16, P: 1282-1291
MYCT1 controls environmental sensing in human haematopoietic stem cells

MYCT1 is identified as a crucial regulator of cellular properties essential for the stemness of human haematopoietic stem cells, a finding that may help improve successful in vitro expansion of these cells for therapeutics.

Júlia Aguadé-Gorgorió
Yasaman Jami-Alahmadi
Hanna K. A. Mikkola
ResearchOpen Access05 Jun 2024
Nature

Volume: 630, P: 412-420
Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids

This paper describes an in vitro method to generate human T cells from hematopoietic stem and progenitor cells (HSPCs). It should be useful for both basic and applied studies using T cells.

Christopher S Seet
Chongbin He
Amélie Montel-Hagen
Research03 Apr 2017
Nature Methods

Volume: 14, P: 521-530
Generation of antigen-specific mature T cells from RAG1^−/−RAG2^−/−B2M^−/− stem cells by engineering their microenvironment

Antigen-restricted mature T cells can be generated from pluripotent stem cells edited to lack endogenous T cell receptors and class I major histocompatibility complexes by introducing the T cell selection components into the stromal microenvironment.

Patrick C Chang
Xuegang Yuan
Gay M. Crooks
ResearchOpen Access07 Dec 2023
Nature Biomedical Engineering

Volume: 8, P: 461-478
MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment

MLLT3 is identified as a crucial regulator of the self-renewal of human haematopoietic stem cells, and helps to maintain an active chromatin state in haematopoietic stem-cell regulatory genes during culture.

Vincenzo Calvanese
Andrew T. Nguyen
Hanna K. A. Mikkola
Research27 Nov 2019
Nature

Volume: 576, P: 281-286
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

Holt et al. describe an anti-HIV strategy in which human hematopoietic stem/progenitor cells are modified with zinc-finger nucleases to knock out the viral co-receptor CCR5. Transplantation of these cells into mice confers resistance to HIV, as shown by higher human T-cell counts and lower viral loads compared with animals that received unmodified cells.

Nathalia Holt
Jianbin Wang
Paula M Cannon
Research02 Jul 2010
Nature Biotechnology

Volume: 28, P: 839-847
Medial HOXA genes demarcate haematopoietic stem cell fate during human development

Mikkola and colleagues show that medial HOXA gene expression, induced by retinoic acid signalling, marks the establishment of the definitive HSC fate and controls HSC identity and function.

Diana R. Dou
Vincenzo Calvanese
Hanna K. A. Mikkola
Research16 May 2016
Nature Cell Biology

Volume: 18, P: 595-606
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
The unpredictable stem cell

How individual hematopoietic stem cells contribute to blood cell formation throughout a lifetime has remained a subject of debate. A new analysis suggests there is substantial variation in hematopoietic stem cell fate and self-renewal activity.

Gay M Crooks
Kenneth Weinberg
News & Views01 Nov 2006
Nature Immunology

Volume: 7, P: 1129-1130
Uncertainty Plagues US Stem Cell Research

Gay M Crooks
News01 Nov 2010
Pediatric Research

Volume: 68, P: 373

Search

Engraftment of gene–modified umbilical cord blood cells in neonates with adenosine deaminase deficiency

T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34⁺ cells in ADA-deficient SCID neonates

Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin

Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages

MYCT1 controls environmental sensing in human haematopoietic stem cells

Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids

Generation of antigen-specific mature T cells from RAG1^−/−RAG2^−/−B2M^−/− stem cells by engineering their microenvironment

MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment

Mapping the human genetic architecture of COVID-19

Whole-genome sequencing reveals host factors underlying critical COVID-19

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

Medial HOXA genes demarcate haematopoietic stem cell fate during human development

A second update on mapping the human genetic architecture of COVID-19

The unpredictable stem cell

Uncertainty Plagues US Stem Cell Research

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