Nature Search

Zeb2 drives invasive and microbiota-dependent colon carcinoma

Van Loo and colleagues report that loss of the Zeb2 regulator of epithelial-to-mesenchymal transition from the intestinal epithelium leads to inflammation, increased intestinal permeability and colorectal cancer development, which is enhanced by the resident intestinal microbiome.

Karolina Slowicka
Ioanna Petta
Geert van Loo
Research15 Jun 2020
Nature Cancer

Volume: 1, P: 620-634
Effects of Vitamin B12 on Performance and Circadian Rhythm in Normal Subjects

Geert Mayer
Margarete Kröger
Karlheinz Meier-Ewert
Research01 Nov 1996
Neuropsychopharmacology

Volume: 15, P: 456-464
Colibactin-driven colon cancer requires adhesin-mediated epithelial binding

The oncogenic potential of pks⁺ Escherichia coli depends critically on bacterial adhesion to host epithelial cells mediated by the type 1 pilus adhesin FimH and the F9 pilus adhesin FmlH.

Maude Jans
Magdalena Kolata
Lars Vereecke
Research06 Nov 2024
Nature

Volume: 635, P: 472-480
Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis

Maintaining the intestinal barrier function requires a balance of multiple signalling pathways. Here the authors show that A20, an anti-inflammatory and anti-apoptotic protein, and Atg1611, an autophagy regulator, cross-regulate their respective protein levels and function to serve compensatory and redundant roles in fine-tuning gut barrier homeostasis.

Karolina Slowicka
Inmaculada Serramito-Gómez
Geert van Loo
ResearchOpen Access23 Apr 2019
Nature Communications

Volume: 10, P: 1-15
A20 controls intestinal homeostasis through cell-specific activities

Aetiology of colitis is highly complex and incompletely understood. Here the authors show in mouse models that A20 deubiquitinase limits pro-inflammatory cytokine production in myeloid cells while inhibiting proapoptotic response to these cytokines in enterocytes, and that only upon losing both functions intestinal pathologies develop.

Lars Vereecke
Sara Vieira-Silva
Geert van Loo
Research30 Sept 2014
Nature Communications

Volume: 5, P: 1-12
Erratum: Narcolepsy is strongly associated with the T-cell receptor alpha locus

Joachim Hallmayer
Juliette Faraco
Emmanuel Mignot
Amendments and Corrections01 Jul 2009
Nature Genetics

Volume: 41, P: 859
Synthetic O-acetylated sialosides facilitate functional receptor identification for human respiratory viruses

The specificity of human and animal viruses that engage with O-acetylated sialic acids has now been probed using a collection of O-acetylated sialoglycans obtained by diversification of trisaccharide precursors with viral haemagglutinin–esterases. The results revealed host-specific patterns of receptor recognition and showed that human respiratory viruses uniquely employ 9-O-acetylated α2,8-linked disialosides as receptors.

Zeshi Li
Yifei Lang
Geert-Jan Boons
Research22 Mar 2021
Nature Chemistry

Volume: 13, P: 496-503
Correction: Corrigendum: Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy

Hyun Hor
Zoltán Kutalik
Mehdi Tafti
Amendments and Corrections29 Mar 2011
Nature Genetics

Volume: 43, P: 388
Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

Narcolepsy has genetic and environmental risk factors, but the specific genetic risk loci and interaction with environmental triggers are not well understood. Here, the authors identify genetic loci for narcolepsy, suggesting infection as a trigger and dendritic and helper T cell involvement.

Hanna M. Ollila
Eilon Sharon
Emmanuel J. Mignot
ResearchOpen Access15 May 2023
Nature Communications

Volume: 14, P: 1-13
Narcolepsy is strongly associated with the T-cell receptor alpha locus

Emmanuel Mignot and colleagues report that variants in the T-cell receptor alpha (TRA@) locus are strongly associated with narcolepsy. This is the first documented involvement of the TCR locus in human disease and will shed light on how HLA-TCR interactions contribute to organ-specific autoimmune targeting.

Joachim Hallmayer
Juliette Faraco
Emmanuel Mignot
Research03 May 2009
Nature Genetics

Volume: 41, P: 708-711
Exploring the clinical features of narcolepsy type 1 versus narcolepsy type 2 from European Narcolepsy Network database with machine learning

Zhongxing Zhang
Geert Mayer
Ramin Khatami
ResearchOpen Access13 Jul 2018
Scientific Reports

Volume: 8, P: 1-11
The interferon-related developmental regulator 1 is used by human papillomavirus to suppress NFκB activation

Human papillomavirus employs immune evasion strategies to establish a long-term infection. Here the authors show that the virus in the EGFR-dependent manner induces IFRD1, which blocks NFκB activating acetylation, and that this process can be suppressed by the EGFR inhibitor cetuximab.

Bart Tummers
Renske Goedemans
Sjoerd H. van der Burg
ResearchOpen Access13 Mar 2015
Nature Communications

Volume: 6, P: 1-12
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

This study provides evidence for a critical role of RIPK1 in suppressing caspase-8-mediated cell death and maintaining intestinal homeostasis independently of its kinase activity.

Nozomi Takahashi
Lars Vereecke
Peter Vandenabeele
Research03 Sept 2014
Nature

Volume: 513, P: 95-99
OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection

Lien Verboom
Christopher J. Anderson
Geert van Loo
ResearchOpen Access19 Aug 2023
Cell Death & Disease

Volume: 14, P: 1-13
Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy

Mehdi Tafti and colleagues identify new HLA class II haplotypes that are strongly protective against narcolepsy. Their analyses suggest a virtually causal role for the HLA region in determining narcolepsy susceptibility.

Hyun Hor
Zoltán Kutalik
Mehdi Tafti
Research15 Aug 2010
Nature Genetics

Volume: 42, P: 786-789
Role for c-Abl and p73 in the radiation response of male germ cells

Geert Hamer
Iris S Gademan
Dirk G de Rooij
Research19 Jul 2001
Oncogene

Volume: 20, P: 4298-4304
Narcolepsy — clinical spectrum, aetiopathophysiology, diagnosis and treatment

In the past 20 years, understanding of the clinical manifestations, aetiopathophysiology, diagnosis and treatment of narcolepsy has greatly advanced. In this Review, Bassetti et al. present these advances, discuss unmet needs and offer future perspectives for the field of narcolepsy.

Claudio L. A. Bassetti
Antoine Adamantidis
Yves Dauvilliers
Reviews19 Jul 2019
Nature Reviews Neurology

Volume: 15, P: 519-539

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