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Showing 1–5 of 5 results
Advanced filters: Author: Gemma Mendel Clear advanced filters

  • Prostate cancer (PrCa) involves a large heritable genetic component. Here, the authors perform multivariate fine-mapping of known PrCa GWAS loci, identifying variants enriched for biological function, explaining more familial relative risk, and with potential application in clinical risk profiling.

    • Tokhir Dadaev
    • Edward J. Saunders
    • Zsofia Kote-Jarai
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-19

  • This Perspectives describes the characteristics of stem and progenitor cells in the liver, biliary tree and pancreas. A hypothetical model of maturational cell lineages is presented, highlighting the common embryological origin of these organs. The potential of these stem and progenitor cells in regenerative medicine is discussed, along with their role in the pathophysiology and oncogenesis of midgut organs.

    • Vincenzo Cardinale
    • Yunfang Wang
    • Domenico Alvaro
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 9, P: 231-240

  • Systemic dissection of sexually dimorphic phenotypes in mice is lacking. Here, Karp and the International Mouse Phenotype Consortium show that approximately 10% of qualitative traits and 56% of quantitative traits in mice as measured in laboratory setting are sexually dimorphic.

    • Natasha A. Karp
    • Jeremy Mason
    • Jacqueline K. White
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • The full extent of the genetic basis for hearing impairment is unknown. Here, as part of the International Mouse Phenotyping Consortium, the authors perform a hearing loss screen in 3006 mouse knockout strains and identify 52 new candidate genes for genetic hearing loss.

    • Michael R. Bowl
    • Michelle M. Simon
    • Steve D. M. Brown
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11