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Showing 1–4 of 4 results
Advanced filters: Author: Gene G. Olinger Clear advanced filters

  • Vaccines that protect nonhuman primates from lethal Ebola virus infection have been developed, but their protective mechanisms have not been clearly delineated. Nancy Sullivan et al. now report that the protective efficacy of a recombinant Ad5-based Ebola virus vaccine relies primarily on CD8+ T cells rather than on antibodies. The findings suggest that clinical development of T cell–based vaccines against Ebola virus is warranted.

    • Nancy J Sullivan
    • Lisa Hensley
    • Gary J Nabel
    Research
    Nature Medicine
    Volume: 17, P: 1128-1131

  • Unmet need exists for a vaccine against Middle East respiratory syndrome coronavirus (MERS-CoV). Here the authors report the establishment and evaluation, in mice and primates, of a series of MERS-CoV immunogens and show that they can serve as promising leads for vaccine development.

    • Lingshu Wang
    • Wei Shi
    • Barney S. Graham
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • A new treatment, containing an optimized cocktail of three monoclonal antibodies against Ebola virus, provided full protection and disease reversal in rhesus monkeys when given under conditions in which controls succumbed by day 8; this new therapy may be a good candidate for treating Ebola virus infection in human patients.

    • Xiangguo Qiu
    • Gary Wong
    • Gary P. Kobinger
    Research
    Nature
    Volume: 514, P: 47-53