A complex and highly regulated pathway ensures that the delivery of cytotoxic cargo of cytotoxic lymphocytes is appropriately aimed and timed. As reviewed here, the study of patients and mutant mice with cytotoxicity defects has revealed many of the molecules involved in this targeted exocytosis of cytotoxic granules.
- Geneviève de Saint Basile
- Gaël Ménasché
- Alain Fischer
