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Advanced filters: Author: Gengo Kashiwazaki Clear advanced filters

Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA

5-hydroxymethyluracil (hmU) is an oxidative DNA lesion and a potential intermediate in DNA repair–coupled DNA demethylation pathways. Isotopic labeling and MS reveal that hmU is produced directly by Tet-mediated oxidation of thymine in mouse embryonic stem cells, suggesting a functional role for hmU in stem cells.

Toni Pfaffeneder
Fabio Spada
Thomas Carell
Research18 May 2014
Nature Chemical Biology

Volume: 10, P: 574-581
RUNX1 positively regulates the ErbB2/HER2 signaling pathway through modulating SOS1 expression in gastric cancer cells

Yoshihide Mitsuda
Ken Morita
Yasuhiko Kamikubo
ResearchOpen Access23 Apr 2018
Scientific Reports

Volume: 8, P: 1-13
Autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells

Ken Morita
Mina Noura
Yasuhiko Kamikubo
ResearchOpen Access30 Nov 2017
Scientific Reports

Volume: 7, P: 1-12

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