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Showing 1–6 of 6 results
Advanced filters: Author: Gennady Bratslavsky Clear advanced filters

  • For decades, complete removal of the kidney with all the contents of the Gerota's fascia (including the adrenal gland) has been a standard procedure for treating renal cell carcinoma (RCC). Two recent articles argue against routine adrenalectomy, and encourage adrenal preservation for the vast majority of patients with RCC.

    • Gennady Bratslavsky
    • W. Marston Linehan
    News & Views
    Nature Reviews Urology
    Volume: 8, P: 534-536

  • In this Review, Bratslavsky and Linehan address the management of the challenging group of patients with bilateral, multifocal, recurrent renal cell carcinoma. They discuss the treatment options and outcomes for these patients, highlight the importance of maximal renal preservation, and outline a management strategy developed from their own experience in treating these patients.

    • Gennady Bratslavsky
    • W. Marston Linehan
    Reviews
    Nature Reviews Urology
    Volume: 7, P: 267-275

  • Hsp90 is required for the folding, stability and activity of several drivers of oncogenesis. Here the authors show that Folliculin-interacting proteins (FNIP) 1 and 2, whose expression correlates with the cellular response to Hsp90 inhibitors, are co-chaperones of Hsp90 that function by inhibiting its ATPase activity.

    • Mark R. Woodford
    • Diana M. Dunn
    • Mehdi Mollapour
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15

  • In some instances (<5%), non-muscle-invasive bladder cancer can progress to metastatic disease without any signs of bladder muscle or lympho-vascular invasion, a condition known as metastatic non-muscle-invasive bladder cancer. In this Perspective, the authors present the available literature on metastatic non-muscle-invasive bladder cancer, and discuss the potential aetiologies underlying this condition.

    • Michael Leyderman
    • Thenappan Chandrasekar
    • Hanan Goldberg
    Reviews
    Nature Reviews Urology
    Volume: 22, P: 375-386

  • Several therapeutic options for the treatment of renal cell carcinoma (RCC) are available, but challenges in the field such as drug resistance still exist. In this Perspective, Sager et. al discuss the role and the inhibition of the cyclin-dependent kinases CDK4 and CDK6 in RCC. The role of CDK4/6 at the interface between metabolic signalling pathways and cell cycle, the wide use of CDK4/6 inhibitors in cancer treatment, and promising preclinical studies testing these drugs in RCC support further investigation of CDK4/6 targeting in RCC.

    • Rebecca A. Sager
    • Sarah J. Backe
    • Mehdi Mollapour
    Reviews
    Nature Reviews Urology
    Volume: 19, P: 305-320