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The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells

MicroRNAs can posttranscriptionally repress multiple targets in a cell population. Here the authors use single-cell sequencing to investigate the effects of an individual miRNA on transcriptional heterogeneity and gene co-expression

Gennaro Gambardella
Annamaria Carissimo
Robert Blelloch
ResearchOpen Access19 Jan 2017
Nature Communications

Volume: 8, P: 1-11
Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes

Some individuals present with multiple synchronous colorectal tumours, but the genetic understanding of this is unclear. Here, the authors use a sequencing strategy to show that the synchronous tumours are genetically independent and the patients harbour rare germline damaging mutations in genes associated with the immune system.

Matteo Cereda
Gennaro Gambardella
Francesca D. Ciccarelli
ResearchOpen Access05 Jul 2016
Nature Communications

Volume: 7, P: 1-12
Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition

Cancer of unknown primary (CUP) is a mysterious malignancy featuring metastatic dissemination in the absence of a recognizable primary tumor. By characterizing CUP cancer stem cells we show that self-sustained long-term propagation and sensitivity to MEK inhibition are CUP common features.

Federica Verginelli
Alberto Pisacane
Carla Boccaccio
ResearchOpen Access03 May 2021
Nature Communications

Volume: 12, P: 1-16
Fibroblast growth factor signalling controls nervous system patterning and pigment cell formation in Ciona intestinalis

The fibroblast growth factor (FGF) signalling pathway specifies the fate of pigmented cells in the ascidian Ciona intestinalis. Here, the authors obtain lineage-specific transcription profiles of pigment precursor cells and identify FGF downstream genes involved in central nervous system patterning, and the specification and differentiation of pigmented cells.

Claudia Racioppi
Ashwani K. Kamal
Filomena Ristoratore
ResearchOpen Access05 Sept 2014
Nature Communications

Volume: 5, P: 1-17
Irinotecan plus leucovorin-modulated 5-fluorouracil I.V. bolus every other week may be a suitable therapeutic option also for elderly patients with metastatic colorectal carcinoma

P Comella
A Farris
A Gambardella
ResearchOpen Access09 Sept 2003
British Journal of Cancer

Volume: 89, P: 992-996

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The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells

Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes

Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition

Fibroblast growth factor signalling controls nervous system patterning and pigment cell formation in Ciona intestinalis

Irinotecan plus leucovorin-modulated 5-fluorouracil I.V. bolus every other week may be a suitable therapeutic option also for elderly patients with metastatic colorectal carcinoma

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The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells

Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes

Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition

Fibroblast growth factor signalling controls nervous system patterning and pigment cell formation in Ciona intestinalis

Irinotecan plus leucovorin-modulated 5-fluorouracil I.V. bolus every other week may be a suitable therapeutic option also for elderly patients with metastatic colorectal carcinoma

Search

Quick links