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Showing 1–2 of 2 results
Advanced filters: Author: Genqing Liang Clear advanced filters

  • Age-related macular degeneration is characterized by lipid-rich drusen deposits underneath the retinal pigment epithelium (RPE). Here the authors report an in vitro iPSC-RPE model for AMD that recapitulates drusen and RPE atrophy, and identify two drugs that reduce drusen deposits and restore RPE epithelial phenotype.

    • Ruchi Sharma
    • Aman George
    • Kapil Bharti
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • A genome-wide analysis determines the contribution of DNA breaks and nuclear interactions to the formation of random versus recurrent translocations; whereas random translocations follow nuclear interaction profiles, the frequency of recurrent translocations is directly proportional to the amount of DNA damage at translocation partners.

    • Ofir Hakim
    • Wolfgang Resch
    • Rafael Casellas
    Research
    Nature
    Volume: 484, P: 69-74