Nature Search

Absolute far-field displacements from the 28 June 1992 Landers earthquake sequence

Geoffrey Blewitt
Michael B. Heflin
James F. Zumberge
Research28 Jan 1993
Nature

Volume: 361, P: 340-342
Large language models for scientific discovery in molecular property prediction

Zheng et al. developed LLM4SD, a framework using large language models to predict molecular properties. The method leverages the ability of large language models to synthesize knowledge from literature and to reason about scientific data with domain expertise.

Yizhen Zheng
Huan Yee Koh
Shirui Pan
Research25 Feb 2025
Nature Machine Intelligence

Volume: 7, P: 437-447
AI-driven protein design

Artificial intelligence is revolutionizing protein design by enabling precise navigation of sequence space and accelerating the creation of functional proteins. In this Review, a practical roadmap guides integration of artificial intelligence tools into design workflows, highlighting structural prediction, generative models and case studies spanning engineering therapeutic proteins to designing new ones.

Huan Yee Koh
Yizhen Zheng
George M. Church
Reviews08 Sept 2025
Nature Reviews Bioengineering

P: 1-23
Lamellar aluminophosphates with surface patterns that mimic diatom and radiolarian microskeletons

Scott Oliver
Alex Kuperman
Geoffrey A. Ozin
Research02 Nov 1995
Nature

Volume: 378, P: 47-50
Spore–pollen evidence for early Oligocene high-latitude cool climatic episode in northern Canada

Geoffrey Norris
Research03 Jun 1982
Nature

Volume: 297, P: 387-389
A lanthanide-rich kilonova in the aftermath of a long gamma-ray burst

A modelling analysis shows that an unusually long gamma-ray burst gave rise to a lanthanide-rich kilonova following the merger of a neutron star–neutron star or of a neutron star–black hole.

Yu-Han Yang
Eleonora Troja
Ignacio Pérez-García
Research21 Feb 2024
Nature

Volume: 626, P: 742-745
Cell size control of development in Saccharomyces cerevisiae

Geoffrey R. Calvert
Ian W. Dawes
Research01 Nov 1984
Nature

Volume: 312, P: 61-63
Selecting the best candidates for resurrecting extinct-in-the-wild plants from herbaria

Reviewing online resources and additional literature on national red lists, 361 extinct seed-plant taxa were identified. Of these, 556 herbarium specimens belonging to 161 extinct species were found to have a high ‘de-extinction candidate’ score.

Giulia Albani Rocchetti
Angelino Carta
Thomas Abeli
Research19 Dec 2022
Nature Plants

Volume: 8, P: 1385-1393
Digital technology and service tradability: evidence from patent innovations and knowledge utilization

LEI WANG
Yihan Chen
Geoffrey Hewings
ResearchOpen Access01 Jul 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-18
Author Correction: Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

Kate Lawrenson
Siddhartha Kar
Simon A. Gayther
Amendments and CorrectionsOpen Access08 Sept 2025
Nature Communications

Volume: 16, P: 1-2
Physicochemical graph neural network for learning protein–ligand interaction fingerprints from sequence data

Predicting the binding affinity between small-molecule ligands and proteins is a key task in drug discovery; however, sequence-based methods are often less accurate than structure-based ones. Koh et al. develop a graph neural network using physicochemical constraints that discovers interactions between small molecules and proteins directly from sequence data and that can achieve state-of-the-art performance without the need for costly, experimental 3D structures.

Huan Yee Koh
Anh T. N. Nguyen
Geoffrey I. Webb
Research17 Jun 2024
Nature Machine Intelligence

Volume: 6, P: 673-687
Shared heritability and functional enrichment across six solid cancers

Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.

Xia Jiang
Hilary K. Finucane
Sara Lindström
ResearchOpen Access25 Jan 2019
Nature Communications

Volume: 10, P: 1-23
Spatially resolved imaging of the inner Fomalhaut disk using JWST/MIRI

JWST mid-infrared images of the nearby star Fomalhaut reveal a complex system of dusty rings and disks, created as debris from planetesimal collisions. These structures suggest the presence of a complex and probably dynamically active planetary system.

András Gáspár
Schuyler Grace Wolff
Geoffrey Bryden
Research08 May 2023
Nature Astronomy

Volume: 7, P: 790-798
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

A region on chromosome 19p13 is associated with the risk of developing ovarian and breast cancer. Here, the authors genotyped SNPs in this region in thousands of breast and ovarian cancer patients and identified SNPs associated with three genes, which were analysed with functional studies.

Kate Lawrenson
Siddhartha Kar
Simon A. Gayther
ResearchOpen Access07 Sept 2016
Nature Communications

Volume: 7, P: 1-22
A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization

Studies of the genetic association between vitamin D and cancer risk have typically been underpowered. Here the authors analyse this using Mendelian Randomisation with more than 70 vitamin D variants obtained from the UK Biobank and large-scale data from various consortia, confirming null associations between vitamin D and most cancers.

Jue-Sheng Ong
Suzanne C. Dixon-Suen
Stuart MacGregor
ResearchOpen Access11 Jan 2021
Nature Communications

Volume: 12, P: 1-10
Genome sequence of the Brown Norway rat yields insights into mammalian evolution

Richard A. Gibbs
George M. Weinstock
Francis Collins
Research01 Apr 2004
Nature

Volume: 428, P: 493-521
Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Research06 May 2020
Nature

Volume: 583, P: 90-95
Identification of nine new susceptibility loci for endometrial cancer

Endometrial cancer is the most common invasive gynaecological cancer in developed countries. Here a meta-analysis identifies an additional nine novel endometrial cancer risk loci and eQTL analysis reveals risk variants associate with reduced expression of negative regulators of oncogenic signal transduction proteins.

Tracy A. O’Mara
Dylan M. Glubb
Deborah J. Thompson
ResearchOpen Access09 Aug 2018
Nature Communications

Volume: 9, P: 1-12
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Breast cancer risk for BRCA1/BRCA2 mutation carriers varies depending on other genetic factors. Here, the authors perform a case-only genome-wide association study and highlight novel loci associated with breast cancer risk for BRCA1/BRCA2 mutation carriers.

Juliette Coignard
Michael Lush
Antonis C. Antoniou
ResearchOpen Access17 Feb 2021
Nature Communications

Volume: 12, P: 1-22
A Radiograph Dataset for the Classification, Localization, and Segmentation of Primary Bone Tumors

Shunhan Yao
Yuanxiang Huang
Jiangning Song
ResearchOpen Access16 Jan 2025
Scientific Data

Volume: 12, P: 1-10
Five endometrial cancer risk loci identified through genome-wide association analysis

Amanda Spurdle, Ian Tomlinson, Douglas Easton and colleagues conduct a GWAS meta-analysis and identify five new risk loci for endometrial cancer. Functional studies show that one risk-associated SNP is located in an active chromatin region that interacts with the KLF5 promoter.

Timothy H T Cheng
Deborah J Thompson
Amanda B Spurdle
Research02 May 2016
Nature Genetics

Volume: 48, P: 667-674
De novo mutations in ATP1A3 cause alternating hemiplegia of childhood

David Goldstein, Mohamad Mikati and colleagues report identification of de novo mutations in ATP1A3 in alternating hemiplegia of childhood, which is a rare neurodevelopmental syndrome characterized by recurrent hemiplegic episodes and distinct neurologic manifestations.

Erin L Heinzen
Kathryn J Swoboda
David B Goldstein
Research29 Jul 2012
Nature Genetics

Volume: 44, P: 1030-1034
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia

Richard Houlston and colleagues identify variants at six loci associated with risk of chronic lymphocytic leukemia. These findings confirm that common, low-penetrance susceptibility alleles contribute to this hematological malignancy and provide new insights into disease etiology.

Maria Chiara Di Bernardo
Dalemari Crowther-Swanepoel
Richard S Houlston
Research31 Aug 2008
Nature Genetics

Volume: 40, P: 1204-1210
Genome-wide association study identifies a common variant associated with risk of endometrial cancer

Amanda Spurdle and colleagues report results of a genome-wide association study of endometrial cancer. They identify a risk variant near HNF1B that has previously been associated with increased risk of prostate cancer and with reduced risk of type 2 diabetes.

Amanda B Spurdle
Deborah J Thompson
Douglas F Easton
Research17 Apr 2011
Nature Genetics

Volume: 43, P: 451-454
Cell graph neural networks enable the precise prediction of patient survival in gastric cancer

Yanan Wang
Yu Guang Wang
Jiangning Song
ResearchOpen Access23 Jun 2022
npj Precision Oncology

Volume: 6, P: 1-12
Inertial cavitation of lyophilized and rehydrated nanoparticles of poly(L-lactic acid) at 835 kHz and 1.8 MPa ultrasound

Pia Hiltl
Alexander Grebner
Geoffrey Lee
ResearchOpen Access21 Aug 2019
Scientific Reports

Volume: 9, P: 1-10
Publisher Correction: Shared heritability and functional enrichment across six solid cancers

Xia Jiang
Hilary K. Finucane
Sara Lindström
Amendments and CorrectionsOpen Access23 Sept 2019
Nature Communications

Volume: 10, P: 1-8
Viral mimicry of cytokines, chemokines and their receptors

Antonio Alcami
Reviews01 Jan 2003
Nature Reviews Immunology

Volume: 3, P: 36-50
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

Malcolm G Dunlop
Sara E Dobbins
Richard S Houlston
Research27 May 2012
Nature Genetics

Volume: 44, P: 770-776
Knowledge-transfer learning for prediction of matrix metalloprotease substrate-cleavage sites

Yanan Wang
Jiangning Song
Hong-Bin Shen
ResearchOpen Access18 Jul 2017
Scientific Reports

Volume: 7, P: 1-15
PhosphoPredict: A bioinformatics tool for prediction of human kinase-specific phosphorylation substrates and sites by integrating heterogeneous feature selection

Jiangning Song
Huilin Wang
Roger J. Daly
ResearchOpen Access31 Jul 2017
Scientific Reports

Volume: 7, P: 1-19
Accurate in silico identification of species-specific acetylation sites by integrating protein sequence-derived and functional features

Yuan Li
Mingjun Wang
Jiangning Song
ResearchOpen Access21 Jul 2014
Scientific Reports

Volume: 4, P: 1-12
SecretEPDB: a comprehensive web-based resource for secreted effector proteins of the bacterial types III, IV and VI secretion systems

Yi An
Jiawei Wang
Jiangning Song
ResearchOpen Access23 Jan 2017
Scientific Reports

Volume: 7, P: 1-10
Crysalis: an integrated server for computational analysis and design of protein crystallization

Huilin Wang
Liubin Feng
Jiangning Song
ResearchOpen Access24 Feb 2016
Scientific Reports

Volume: 6, P: 1-14
GlycoMine^struct: a new bioinformatics tool for highly accurate mapping of the human N-linked and O-linked glycoproteomes by incorporating structural features

Fuyi Li
Chen Li
Trevor Lithgow
ResearchOpen Access06 Oct 2016
Scientific Reports

Volume: 6, P: 1-16
Sequential Membrane Rupture and Vesiculation during Plasmodium berghei Gametocyte Egress from the Red Blood Cell

Maria Andreadaki
Eric Hanssen
Inga Siden-Kiamos
ResearchOpen Access23 Feb 2018
Scientific Reports

Volume: 8, P: 1-13
Smoothing a rugged protein folding landscape by sequence-based redesign

Benjamin T. Porebski
Shani Keleher
Ashley M. Buckle
ResearchOpen Access26 Sept 2016
Scientific Reports

Volume: 6, P: 1-14
Periscope: quantitative prediction of soluble protein expression in the periplasm of Escherichia coli

Catherine Ching Han Chang
Chen Li
Ramakrishnan Nagasundara Ramanan
ResearchOpen Access02 Mar 2016
Scientific Reports

Volume: 6, P: 1-11
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Amendments and Corrections17 Jul 2020
Nature

Volume: 584, P: E2
Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Juliette Coignard
Michael Lush
Antonis C. Antoniou
Amendments and CorrectionsOpen Access14 May 2021
Nature Communications

Volume: 12, P: 1-2
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
A comprehensive database of thermal developmental plasticity in reptiles

Daniel W. A. Noble
Vaughn Stenhouse
Lisa E. Schwanz
ResearchOpen Access17 Jul 2018
Scientific Data

Volume: 5, P: 1-7
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

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