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Showing 1–7 of 7 results
Advanced filters: Author: Geoffrey W McCaughan Clear advanced filters

  • Long-term machine perfusion of human livers outside the body is an emerging field with tremendous potential for the assessment, recovery, and modification of organs prior to transplantation. Here, the authors report the long-term ex situ perfusion of human livers and demonstrate the ability to split and perfuse these organs using a standardised protocol.

    • Ngee-Soon Lau
    • Mark Ly
    • Carlo Pulitano
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Here, English et al. show that after expanding in lymphoid tissues, CD4+ and CD8+ T cells recognising hepatic antigens migrate into specialised vascular liver areas where CD4+ T cells locally license hepatic dendritic cells and further expand CD8+ T cell numbers.

    • Kieran English
    • Rain Kwan
    • Patrick Bertolino
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Developing clinically predictive model systems for evaluating gene transfer and gene editing technologies has become increasingly important. This study introduces human liver ex situ normothermic perfusion as a model to evaluate gene therapy vectors, paving the way for advanced liver disease treatment.

    • Marti Cabanes-Creus
    • Sophia H. Y. Liao
    • Leszek Lisowski
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Disease-specific gut microbiome signatures have been previously defined for patients with liver cirrhosis or hepatocellular carcinoma (HCC). Here the authors examine the composition of the gut microbiota in cirrhotic patients with non-alcoholic fatty liver disease with or without HCC and evaluate how dysbiosis influences peripheral immune responses.

    • Jason Behary
    • Nadia Amorim
    • Amany Zekry
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Vitamin D deficiency is common in patients with cirrhosis and is associated with bone density changes. It is generally recommended that patients with cirrhosis and low bone density receive calcium and vitamin D supplementation, despite a lack of evidence for a role of vitamin D in the pathogenesis or treatment of osteoporosis in cirrhotic patients. This Review revisits the controversy surrounding the role of vitamin D in hepatic bone disease and discusses vitamin D therapy in this setting.

    • Bronwyn A Crawford
    • Eternity D Labio
    • Geoffrey W McCaughan
    Reviews
    Nature Clinical Practice Gastroenterology & Hepatology
    Volume: 3, P: 689-699