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Showing 1–7 of 7 results
Advanced filters: Author: Georg A Böhmig Clear advanced filters
  • Vaulet et al. developed and validated four continuous indices from histological lesion scores to assess kidney transplant rejection, offering an alternative to the Banff categories that reflect the continuous nature of rejection.

    • Thibaut Vaulet
    • Priyanka Koshy
    • Maarten Naesens
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • HLA sensitization greatly increases the risk of transplant rejection and failure. An IgG endopeptidase derived from Streptococcus pyogenes (IdeS) may be an attractive new therapy for desensitization. Recent data indicate that IdeS effectively depletes anti-HLA IgG, creating a therapeutic window for successful renal transplantation in sensitized recipients.

    • Georg A. Böhmig
    • Lionel Rostaing
    News & Views
    Nature Reviews Nephrology
    Volume: 13, P: 666-668
  • The development of effective desensitization strategies has enabled ABO incompatible (ABOi) kidney transplantation to become an established treatment option for patients with end-stage renal disease. Here, the authors review the mechanisms that underlie acceptance and rejection of ABOi grafts, recipient desensitization strategies, patient outcomes and novel treatment strategies that might promote graft acceptance and enable minimization of immunosuppression.

    • Georg A. Böhmig
    • Andreas M. Farkas
    • Thomas Wekerle
    Reviews
    Nature Reviews Nephrology
    Volume: 11, P: 732-747
  • Focal and segmental glomerulosclerosis, or renal scarring, is a debilitating disease. The identification of the molecular mechanisms of its initiation and progression has been limited, thus hampering the development of proper animal models. Dontscho Kerjaschki and his colleagues now report that microRNA-193a is elevated in human cases of the disease and that transgenic expression in mice is sufficient to cause the condition.

    • Christoph A Gebeshuber
    • Christoph Kornauth
    • Dontscho Kerjaschki
    Research
    Nature Medicine
    Volume: 19, P: 481-487