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Showing 1–9 of 9 results
Advanced filters: Author: George Bertsias Clear advanced filters
  • The introduction of mycophenolate mofetil to the treatment armamentarium for lupus nephritis raised the hope that the use of cyclophosphamide, with its toxic effects, would decrease. In this Review, the authors summarize the current knowledge of therapies for proliferative and membranous lupus nephritis and propose a treatment scheme, not of one therapy over another, but one that is tailored to the individual patient profile.

    • George Bertsias
    • Dimitrios T Boumpas
    Reviews
    Nature Clinical Practice Rheumatology
    Volume: 4, P: 464-472
  • A proportion of patients with lupus nephritis, a serious complication of systemic lupus erythematosus, progress to end-stage renal disease (ESRD). Despite major advances in treatment, the results of two new studies show that the incidence of lupus nephritis-associated ESRD has increased and outcomes have not improved in recent years.

    • George K. Bertsias
    • Dimitrios T. Boumpas
    News & Views
    Nature Reviews Rheumatology
    Volume: 7, P: 441-442
  • Renal involvement is common and is a major cause of morbidity in patients with systemic lupus erythematosus. Treatment approaches for lupus nephritis are discussed in this review, based, when available, on data from randomized controlled trials. The authors conclude with their recommendations for the optimum management of this complex and heterogeneous disease.

    • Dimitrios T Boumpas
    • Prodromos Sidiropoulos
    • George Bertsias
    Reviews
    Nature Clinical Practice Rheumatology
    Volume: 1, P: 22-30
  • Neuropsychiatric manifestations are common in patients with SLE, encompass a wide range of neurologic and psychiatric features, and can lead to considerable morbidity and mortality. This Review discusses the challenges associated with the diagnosis and treatment of neuropsychiatric SLE.

    • George K. Bertsias
    • Dimitrios T. Boumpas
    Reviews
    Nature Reviews Rheumatology
    Volume: 6, P: 358-367
  • Daniel Kastner and colleagues report genome-wide association analyses for Behçet's disease, a condition characterized by episodic inflammation of the skin and eyes and an important cause of blindness. They identify four loci newly associated with Behçet's disease, an epistatic interaction between HLA-B*51 and ERAP1 and overlap with loci previously associated to related inflammatory disorders.

    • Yohei Kirino
    • George Bertsias
    • Daniel L Kastner
    Research
    Nature Genetics
    Volume: 45, P: 202-207
  • Systemic lupus erythematosus (SLE) is a heterogeneous condition characterized by a wide range of symptoms, rendering its diagnosis an often difficult task. In this article, the authors highlight the current approaches and challenges in SLE diagnosis, propose an algorithm to facilitate this process, and argue for the development of endorsed diagnostic criteria.

    • George K. Bertsias
    • Cristina Pamfil
    • Dimitrios T. Boumpas
    Reviews
    Nature Reviews Rheumatology
    Volume: 9, P: 687-694
  • This article presents the first Evidence-Based Guideline dedicated specifically to the diagnosis and management of eosinophilic granulomatosis with polyangiitis. The 16 statements and five overarching principles cover the diagnosis and staging, treatment, outcome and follow-up of eosinophilic granulomatosis with polyangiitis.

    • Giacomo Emmi
    • Alessandra Bettiol
    • Augusto Vaglio
    Reviews
    Nature Reviews Rheumatology
    Volume: 19, P: 378-393