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  • Receptor tyrosine kinases can be auto-activated independent of ligand. Sabet et al.show that on ligand stimulation, ephrin receptor EphA2 switches from auto-activation suppression by vesicular recycling to ligand-dependent signalling limited by directional trafficking to late endosomes/lysosomes.

    • Ola Sabet
    • Rabea Stockert
    • Philippe I. H. Bastiaens
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13