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Sotorasib with panitumumab in chemotherapy-refractory KRAS^G12C-mutated colorectal cancer: a phase 1b trial

A substudy of the CodeBreaK 101 trial, this phase 1b trial testing the KRAS-G12C inhibitor sotorasib with an anti-EGFR antibody shows an acceptable safety profile of this combination and encouraging preliminary clinical efficacy in patients with chemotherapy-refractory colorectal cancer.

Yasutoshi Kuboki
Marwan Fakih
David S. Hong
Research04 Jan 2024
Nature Medicine

Volume: 30, P: 265-270
SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts

Sunao Takeshita
Noriyuki Namba
F. Patrick Ross
Research05 Aug 2002
Nature Medicine

Volume: 8, P: 943-949
Activin/TGF-β induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP

Hector Valderrama-Carvajal
Eftihia Cocolakis
Jean-Jacques Lebrun
Research11 Nov 2002
Nature Cell Biology

Volume: 4, P: 963-969
The Selective mGlu5 Receptor Antagonist MTEP, Similar to NMDA Receptor Antagonists, Induces Social Isolation in Rats

Eliza Koros
Holger Rosenbrock
Frank Sams-Dodd
Research14 Jun 2006
Neuropsychopharmacology

Volume: 32, P: 562-576
Saponins in soy reduce NNK-induced lung cancer by increasing plasma isoflavone levels

Ingrid Elisia
Michelle Yeung
Gerald Krystal
ResearchOpen Access13 Apr 2025
Scientific Reports

Volume: 15, P: 1-12
Butyrate and tributyrin reduce LPS-induced inflammatory cytokine production from human visceral fat

Hossein Rafiei
Michelle Yeung
Ingrid Elisia
Research10 Jul 2024
International Journal of Obesity

Volume: 48, P: 1559-1567
A ketogenic diet rich in fish oil is superior to other fats in preventing NNK-induced lung cancer in A/J mice

Ingrid Elisia
Michelle Yeung
Gerald Krystal
ResearchOpen Access07 Mar 2024
Scientific Reports

Volume: 14, P: 1-15
The effect of smoking on chronic inflammation, immune function and blood cell composition

Ingrid Elisia
Vivian Lam
Gerald Krystal
ResearchOpen Access10 Nov 2020
Scientific Reports

Volume: 10, P: 1-16
Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium

Emily L. Dennis
Seth G. Disner
Rajendra A. Morey
Research19 Dec 2019
Molecular Psychiatry

Volume: 26, P: 4315-4330

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