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Showing 1–3 of 3 results
Advanced filters: Author: Gerald Maxwell Cherf Clear advanced filters
  • New delivery platforms are needed to allow broader application of biotherapeutics for CNS diseases. Here, the authors show enhanced CNS delivery with a transport vehicle engineered to bind CD98hc, a highly expressed target at the blood-brain barrier.

    • Kylie S. Chew
    • Robert C. Wells
    • Mihalis S. Kariolis
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17
  • Roy et al. describe a generalized method for computationally designing miniproteins selective for a single integrin heterodimer and conformational state. The designed αvβ6 inhibitor remains monomeric and maintains biological activity following aerosolization and shows excellent efficacy in bleomycin induced lung fibrosis.

    • Anindya Roy
    • Lei Shi
    • David Baker
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18