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Showing 1–3 of 3 results
Advanced filters: Author: Gerald Stampfel Clear advanced filters

  • Enhancers are DNA elements that are key regulators of gene expression, but their complexities and context dependence makes their identification and characterization challenging. This Review discusses how an improved understanding of the varied properties of enhancers is being used in diverse approaches for the systematic prediction of enhancers genome wide.

    • Daria Shlyueva
    • Gerald Stampfel
    • Alexander Stark
    Reviews
    Nature Reviews Genetics
    Volume: 15, P: 272-286

  • Systematically assaying the activity of 7,705 candidate enhancers during Drosophila embryogenesis shows that nearly half are active in the embryo and display dynamic spatial patterns during development; enhancer activity is matched to expression patterns of putative target genes and predictive cis-regulatory motifs are identified.

    • Evgeny Z. Kvon
    • Tomas Kazmar
    • Alexander Stark
    Research
    Nature
    Volume: 512, P: 91-95

  • A large-scale enhancer complementation assay assessing the activating or repressing contributions of over 800 Drosophila transcription factors and cofactors to combinatorial enhancer control reveals a more complex picture than expected, with many factors having diverse regulatory functions that depend on the enhancer context.

    • Gerald Stampfel
    • Tomáš Kazmar
    • Alexander Stark
    Research
    Nature
    Volume: 528, P: 147-151