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Showing 1–15 of 15 results
Advanced filters: Author: Gerard Parr Clear advanced filters

  • This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

    • Britta Kunkemoeller
    • Hannah Prendeville
    • Lydia Lynch
    ResearchOpen Access
    Nature Metabolism
    Volume: 7, P: 1630-1645

  • Whole-exome sequencing in a large autism study identifies over 100 autosomal genes that are likely to affect risk for the disorder; these genes, which show unusual evolutionary constraint against mutations, carry de novo loss-of-function mutations in over 5% of autistic subjects and many function in synaptic, transcriptional and chromatin-remodelling pathways.

    • Silvia De Rubeis
    • Xin He
    • Joseph D. Buxbaum
    Research
    Nature
    Volume: 515, P: 209-215

  • Better analytical methods are needed to extract biological meaning from genome-wide association studies (GWAS) of psychiatric disorders. Here the authors take GWAS data from over 60,000 subjects, including patients with schizophrenia, bipolar disorder and major depression, and identify common etiological pathways shared amongst them.

    • Colm O'Dushlaine
    • Lizzy Rossin
    • Gerome Breen
    Research
    Nature Neuroscience
    Volume: 18, P: 199-209

  • The autism spectrum disorders are complex genetic traits characterized by various neurodevelopmental deficits. Here, the authors analyse defective gene family interaction networks in autism cases and healthy controls and identify potential gene family interactions that may contribute to autism aetiology.

    • Dexter Hadley
    • Zhi-liang Wu
    • Hakon Hakonarson
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-10

  • The food system is increasingly reliant on a multitude of data-driven technologies that connect global supply chains and underpin productivity, trade and security. Improved governance of data exchange — through a data trust framework — will drive sustainable business growth and secure wider public benefits.

    • Steve Brewer
    • Simon Pearson
    • Luc Bidaut
    Comments & Opinion
    Nature Food
    Volume: 2, P: 543-545

  • The autistic spectrum disorders (ASDs) are highly heritable, yet the underlying genetic determinants remain largely unknown. Here, a genome-wide analysis of rare copy number variants (CNVs) has been carried out, revealing that ASD sufferers carry a higher load of rare, genic CNVs than do controls. Many of these CNVs are de novo and inherited. The results implicate several novel genes in ASDs, and point to the importance of cellular proliferation, projection and motility, as well as specific signalling pathways, in these disorders.

    • Dalila Pinto
    • Alistair T. Pagnamenta
    • Catalina Betancur
    Research
    Nature
    Volume: 466, P: 368-372

  • Naomi Wray and colleagues report an analysis of genome-wide association data sets from the Psychiatric Genomics Consortium for five psychiatric disorders. They find that common variation explains 17–29% of the variance in liability and provide further support for a shared genetic etiology for these related psychiatric disorders.

    • S Hong Lee
    • Stephan Ripke
    • Naomi R Wray
    Research
    Nature Genetics
    Volume: 45, P: 984-994

  • Autism is a highly heritable neurodevelopmental disorder, and yet few specific susceptibility genes have been identified to date. A linkage and association mapping study using half a million genome-wide single nucleotide polymorphisms is now described in a common set of 1,031 multiplex autism families. The linkage regions identified provide targets for rare variation screening whereas the discovery of a single novel association, SEMA5A, demonstrates the action of common variants.

    • Lauren A. Weiss
    • Dan E. Arking
    • Leena Peltonen
    Research
    Nature
    Volume: 461, P: 802-808

  • Elise Robinson and colleagues present the polygenic transmission disequilibrium test (pTDT) for evaluating transmission of polygenic risk in family-based study designs. The authors apply pTDT to a cohort of autism spectrum disorder (ASD) families and find that common polygenic variation acts additively with de novo variants to contribute to ASD risk.

    • Daniel J Weiner
    • Emilie M Wigdor
    • Elise B Robinson
    Research
    Nature Genetics
    Volume: 49, P: 978-985

  • In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

    • Jacob Beal
    • Natalie G. Farny
    • Jiajie Zhou
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-29