Nature Search

A mega-analysis of genome-wide association studies for major depressive disorder

Stephan Ripke
Naomi R Wray
Patrick F Sullivan
Research03 Apr 2012
Molecular Psychiatry

Volume: 18, P: 497-511
Heritability and genomics of gene expression in peripheral blood

Fred Wright, Patrick Sullivan and colleagues present the results of a large expression QTL study of peripheral blood using a classic twin design with follow-up replication in independent samples. Their results enable a more precise estimate of the heritability of gene expression and provide a useful resource for exploring the genetic control of transcription.

Fred A Wright
Patrick F Sullivan
Dorret I Boomsma
Research13 Apr 2014
Nature Genetics

Volume: 46, P: 430-437
Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder

Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with symptoms including intrusive thoughts and time-consuming repetitive behaviors. Here Noh and colleagues identify genes enriched for functional variants associated with increased risk of OCD.

Hyun Ji Noh
Ruqi Tang
Kerstin Lindblad-Toh
ResearchOpen Access17 Oct 2017
Nature Communications

Volume: 8, P: 1-13
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

Better analytical methods are needed to extract biological meaning from genome-wide association studies (GWAS) of psychiatric disorders. Here the authors take GWAS data from over 60,000 subjects, including patients with schizophrenia, bipolar disorder and major depression, and identify common etiological pathways shared amongst them.

Colm O'Dushlaine
Lizzy Rossin
Gerome Breen
Research19 Jan 2015
Nature Neuroscience

Volume: 18, P: 199-209
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Naomi Wray and colleagues report an analysis of genome-wide association data sets from the Psychiatric Genomics Consortium for five psychiatric disorders. They find that common variation explains 17–29% of the variance in liability and provide further support for a shared genetic etiology for these related psychiatric disorders.

S Hong Lee
Stephan Ripke
Naomi R Wray
Research11 Aug 2013
Nature Genetics

Volume: 45, P: 984-994
Convergence of evidence from a methylome-wide CpG-SNP association study and GWAS of major depressive disorder

Karolina A. Aberg
Andrey A. Shabalin
Edwin J. C. G. van den Oord
ResearchOpen Access22 Aug 2018
Translational Psychiatry

Volume: 8, P: 1-10
Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples

Karolina A. Aberg
Brian Dean
Edwin J. C. G. van den Oord
Research21 Sept 2018
Molecular Psychiatry

Volume: 25, P: 1344-1354
A methylation study of long-term depression risk

Shaunna L. Clark
Mohammad W. Hattab
Edwin J. C. G. van den Oord
Research09 Sept 2019
Molecular Psychiatry

Volume: 25, P: 1334-1343
Novel neuronal surface autoantibodies in plasma of patients with depression and anxiety

Shenghua Zong
Carolin Correia-Hoffmann
Pilar Martinez-Martinez
ResearchOpen Access23 Nov 2020
Translational Psychiatry

Volume: 10, P: 1-10
The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects

W J Peyrot
S H Lee
B W J H Penninx
Research28 Apr 2015
Molecular Psychiatry

Volume: 20, P: 735-743
Huntingtin gene repeat size variations affect risk of lifetime depression

Sarah L. Gardiner
Martine J. van Belzen
N. Ahmad Aziz
ReviewsOpen Access11 Dec 2017
Translational Psychiatry

Volume: 7, P: 1-8
Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Liz Rietschel
Fabian Streit
Marcella Rietschel
ResearchOpen Access10 Nov 2017
Scientific Reports

Volume: 7, P: 1-15

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