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Showing 1–14 of 14 results
Advanced filters: Author: Gerd R. Burmester Clear advanced filters

  • Evidence presented in 2011 suggests that rheumatoid arthritis might comprise two separate diseases—each with different etiological underpinnings—and that kinase inhibitors could soon be added to the therapeutic armamentarium. Together with new definitions of remission, these advances could aid the development of personalized, treat-to-target strategies.

    • Gerd R. Burmester
    News & Views
    Nature Reviews Rheumatology
    Volume: 8, P: 65-66

  • There have been many exciting advances in tissue engineering. This Viewpoint discusses the future application of this technology in the chronic rheumatic diseases, focusing on the advantages of methods of cartilage regeneration, such as scaffolds, gels, cell-seeding, fibers or cell cultures.

    • Michael Sittinger
    • Gerd R Burmester
    Reviews
    Nature Clinical Practice Rheumatology
    Volume: 2, P: 172-173

  • A considerable increase in the risk of developing cardiovascular disease is conveyed not only by inflammation, but also by the use of glucocorticoids to treat inflammation. In this Viewpoint, the authors discuss the challenge of balancing the relative benefits and hazards of glucocorticoid treatment for inflammatory diseases, as well as the tantalizing prospect of identifying subgroups of the population at risk for cardiovascular disease.

    • Frank Buttgereit
    • Gerd-Rüdiger Burmester
    • Brian J Lipworth
    Reviews
    Nature Clinical Practice Rheumatology
    Volume: 5, P: 18-19

  • B-cell-directed therapies for autoimmune diseases have been the focus of extensive research during the past few years. In this Review, the authors discuss therapies that directly and indirectly target B cells. They outline clinical experience to date, mechanisms of action at the cellular level and possible issues of relevance to the efficacy and safety of these therapeutics.

    • Thomas Dörner
    • Andreas Radbruch
    • Gerd R. Burmester
    Reviews
    Nature Reviews Rheumatology
    Volume: 5, P: 433-441

  • Glucocorticoids are cost-effective drugs that exert strong anti-inflammatory and immunosuppressive effects. However, there is increasing awareness of their potential adverse effects. Although Cushingoid appearance and weight gain have been known for decades, modern measurements of body composition now enable detailed insights into glucocorticoid-induced changes in fat mass and redistribution.

    • Frank Buttgereit
    • Gerd R. Burmester
    News & Views
    Nature Reviews Rheumatology
    Volume: 12, P: 444-445

  • Although advances in therapy of rheumatoid arthritis (RA) have greatly improved disease outcomes, a considerable portion of patients still do not attain clinical remission. Thus, new treatments targeting a range of cytokines and cell types are being explored. This Review outlines these novel approaches to RA therapy.

    • Gerd R. Burmester
    • Eugen Feist
    • Thomas Dörner
    Reviews
    Nature Reviews Rheumatology
    Volume: 10, P: 77-88

  • Tissue engineering and regenerative medicine hold great promise for the treatment of joint and cartilage destruction in rheumatic disease. Here, the authors describe the progress in this field, focusing on the clinical aspects of these emerging therapies and exploring the scientific and regulatory challenges in translating these tissue engineering approaches to the clinic.

    • Jochen Ringe
    • Gerd R. Burmester
    • Michael Sittinger
    Reviews
    Nature Reviews Rheumatology
    Volume: 8, P: 493-498

  • Erdheim–Chester disease is a rare form of non-Langerhans cell histiocytosis characterized by foamy histiocyte infiltration of the skeleton and viscera. A case of Erdheim–Chester disease that was initially mistaken for Ormond's disease is presented with a discussion of the tests required to differentiate between the two diagnoses.

    • Konstanze Loddenkemper
    • Bimba Hoyer
    • Gerd-Rüdiger Burmester
    Reviews
    Nature Clinical Practice Rheumatology
    Volume: 4, P: 50-55

  • The field of rheumatology has seen remarkable progress in the past 70 years. This Perspectives article provides a concise overview of developments in the diagnosis and management of musculoskeletal rheumatic diseases, and what the future of rheumatology might hold.

    • Gerd R. Burmester
    • Johannes W. J. Bijlsma
    • Iain B. McInnes
    Reviews
    Nature Reviews Rheumatology
    Volume: 13, P: 443-448

  • In this Perspective article, members of the European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases discuss clinical and organizational challenges in this community caused by the COVID-19 pandemic and what lessons might be learned for the future.

    • Rosaria Talarico
    • Silvia Aguilera
    • Marta Mosca
    Reviews
    Nature Reviews Rheumatology
    Volume: 17, P: 177-184

  • Rheumatoid arthritis is a chronic, inflammatory, autoimmune disease that primarily affects the joints. This Primer by Smolen et al. provides the latest insights into the epidemiology, genetics, pathophysiology, diagnostic approaches, clinical assessment and management of rheumatoid arthritis.

    • Josef S. Smolen
    • Daniel Aletaha
    • Kazuhiko Yamamoto
    Reviews
    Nature Reviews Disease Primers
    Volume: 4, P: 1-23