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Showing 1–5 of 5 results
Advanced filters: Author: Gerd-Rüdiger Burmester Clear advanced filters
  • CD38 is highly expressed by antibody-secreting cells (ASC) and depleting antibodies targeting CD38 have the potential to treat autoimmune diseases with ASC involvement. Here authors treat systemic lupus erythematosus patients with the ASC-depleting anti-CD38 monoclonal antibody daratumumab in addition to dexamethasone in the frame of a single arm, open-label phase 2 clinical trial to show marked improvements in their clinical and immunological status.

    • Lennard Ostendorf
    • Jan Zernicke
    • Tobias Alexander
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-12
  • A considerable increase in the risk of developing cardiovascular disease is conveyed not only by inflammation, but also by the use of glucocorticoids to treat inflammation. In this Viewpoint, the authors discuss the challenge of balancing the relative benefits and hazards of glucocorticoid treatment for inflammatory diseases, as well as the tantalizing prospect of identifying subgroups of the population at risk for cardiovascular disease.

    • Frank Buttgereit
    • Gerd-Rüdiger Burmester
    • Brian J Lipworth
    Reviews
    Nature Clinical Practice Rheumatology
    Volume: 5, P: 18-19
  • Erdheim–Chester disease is a rare form of non-Langerhans cell histiocytosis characterized by foamy histiocyte infiltration of the skeleton and viscera. A case of Erdheim–Chester disease that was initially mistaken for Ormond's disease is presented with a discussion of the tests required to differentiate between the two diagnoses.

    • Konstanze Loddenkemper
    • Bimba Hoyer
    • Gerd-Rüdiger Burmester
    Reviews
    Nature Clinical Practice Rheumatology
    Volume: 4, P: 50-55