Although neutrophils have crucial functions in microbial killing, they can also trigger tissue damage via the release of reactive oxygen species and proinflammatory mediators. Robert Zeiser and colleagues now report that neutrophils also contribute to the severity of graft-versus-host disease following translocation of bacteria in the gut induced by the conditioning regimen for allogeneic hematopoietic cell transplantation.
- Lukas Schwab
- Luise Goroncy
- Robert Zeiser
