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Correction: Corrigendum: Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice

Martina Schweiger
Matthias Romauch
Rudolf Zechner
Amendments and CorrectionsOpen Access25 Apr 2017
Nature Communications

Volume: 8, P: 1
Functionally overlapping intra- and extralysosomal pathways promote bis(monoacylglycero)phosphate synthesis in mammalian cells

Bis(monoacylglycero)phosphate (BMP) is an important component of late endosomal and lysosomal membranes. In this study, the authors show that both intra- and extralysosomal pathways can contribute to BMP synthesis.

Dominik Bulfon
Johannes Breithofer
Robert Zimmermann
ResearchOpen Access16 Nov 2024
Nature Communications

Volume: 15, P: 1-17
Mutational scanning pinpoints distinct binding sites of key ATGL regulators in lipolysis

ATGL is a key enzyme in intracellular lipolysis. Here, the authors use deep mutational scanning to define the determinants of protein interaction between ATGL and its regulatory partners, gaining insights into lipolysis mechanisms in cells.

Johanna M. Kohlmayr
Gernot F. Grabner
Ulrich Stelzl
ResearchOpen Access21 Mar 2024
Nature Communications

Volume: 15, P: 1-15
Development of small-molecule inhibitors targeting adipose triglyceride lipase

A competitive inhibitor of the lipase ATGL reduces the availability of adipocyte fatty acids, causing insulin resistance in insulin-sensitive tissues.

Nicole Mayer
Martina Schweiger
Rolf Breinbauer
Research06 Oct 2013
Nature Chemical Biology

Volume: 9, P: 785-787
Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice

The enzyme Atgl participates in the breakdown of lipids in adipose tissue. Here the authors show that pharmacological inhibition of Atgl reduces weight gain and improves metabolic health in mice fed a high-fat diet, without causing adverse effects in cardiac muscle associated with genetic depletion ofAtgl.

Martina Schweiger
Matthias Romauch
Rudolf Zechner
ResearchOpen Access22 Mar 2017
Nature Communications

Volume: 8, P: 1-15
Lipolysis: cellular mechanisms for lipid mobilization from fat stores

Zechner and colleagues discuss mechanisms facilitating the mobilization of intracellular fatty acids and how they affect lipid-mediated signalling, metabolic regulation and energy homeostasis in health and disease.

Gernot F. Grabner
Hao Xie
Rudolf Zechner
Reviews19 Nov 2021
Nature Metabolism

Volume: 3, P: 1445-1465

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Correction: Corrigendum: Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice

Functionally overlapping intra- and extralysosomal pathways promote bis(monoacylglycero)phosphate synthesis in mammalian cells

Mutational scanning pinpoints distinct binding sites of key ATGL regulators in lipolysis

Development of small-molecule inhibitors targeting adipose triglyceride lipase

Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice

Lipolysis: cellular mechanisms for lipid mobilization from fat stores

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