Various cardiovascular and noncardiovascular drugs, including so-called antiarrhythmic drugs, can induce cardiac arrhythmias. In this Review, Frommeyer and Eckardt summarize important proarrhythmic risk factors (such as age, female sex, and structural heart disease) and the underlying electrophysiological mechanisms (such as spatial or temporal dispersion of repolarization, alterations in action-potential morphology, and development of early afterdepolarizations).
- Gerrit Frommeyer
- Lars Eckardt
