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Showing 1–2 of 2 results
Advanced filters: Author: Gert Trausinger Clear advanced filters

  • Although ageing is the most important risk factor for chronic ailments, effective interventions remain rare. Here, the authors identify the flavonoid 4,4’-dimethoxychalcone and demonstrate that it extends lifespan and promotes health in multiple organisms by inducing autophagy.

    • Didac Carmona-Gutierrez
    • Andreas Zimmermann
    • Frank Madeo
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Spermidine, a naturally occurring polyamine, extends the lifespan of mice and is cardioprotective in both aged mice and hypertensive rats. In humans, high dietary spermidine intake is associated with reduced blood pressure and a lower incidence of cardiovascular disease.

    • Tobias Eisenberg
    • Mahmoud Abdellatif
    • Frank Madeo
    Research
    Nature Medicine
    Volume: 22, P: 1428-1438