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A redundant transcription factor network steers spatiotemporal Arabidopsis triterpene synthesis

Plant specialized metabolite biosynthesis is strictly regulated in time and space. The authors describe a robust and redundant transcriptional network that steers cell-specific and jasmonate-inducible triterpene biosynthesis in Arabidopsis root tips.

Trang Hieu Nguyen
Louis Thiers
Alain Goossens
Research15 May 2023
Nature Plants

Volume: 9, P: 926-937
Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium

PEGylated liposomal accumulation in inflamed regions has mainly been attributed to the enhanced permeation and retention effect. An arthritis model that chemotactically attracted myeloid cells shows that monocytes and neutrophils play an essential role in liposome delivery towards inflamed joints.

Joke Deprez
Rein Verbeke
Ine Lentacker
Research10 Jul 2023
Nature Nanotechnology

Volume: 18, P: 1341-1350
Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space

Adriaenssens et al. provide evidence suggesting that cytosolic small heat shock proteins localize to the mitochondrial intermembrane space, where they operate as molecular chaperones.

Elias Adriaenssens
Bob Asselbergh
Vincent Timmerman
ResearchOpen Access23 Jan 2023
Nature Cell Biology

Volume: 25, P: 467-480
Non-cell autonomous and spatiotemporal signalling from a tissue organizer orchestrates root vascular development

Cytokinin influences various aspects of plant growth and development, including vascular development. The TMO5/LHW complex regulates a precise balance of cytokinin in xylem and procambium, therefore organizing root vascular patterning in Arabidopsis.

BaoJun Yang
Max Minne
Bert De Rybel
Research15 Nov 2021
Nature Plants

Volume: 7, P: 1485-1494
Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival

Tavernier et al. show that loss of the protective IRE1–XBP1 stress sensor results in the death of conventional dendritic cells in the lung, whereas those in the intestine survive due to a stronger ATF4-dependent stress response and RIDD activation.

Simon J. Tavernier
Fabiola Osorio
Sophie Janssens
Research01 May 2017
Nature Cell Biology

Volume: 19, P: 698-710
A coherent transcriptional feed-forward motif model for mediating auxin-sensitive PIN3 expression during lateral root development

Lateral root development is dependent on precise control of the distribution of the plant hormone auxin. Here Chen et al. propose the transcription factors ARF7 and FLP participate in a feed forward motif to mediate expression of the auxin transporter PIN3and consequently regulate lateral root development.

Qian Chen
Yang Liu
Steffen Vanneste
ResearchOpen Access18 Nov 2015
Nature Communications

Volume: 6, P: 1-12
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

Van Hove et al. reveal the diversity of macrophages at the brain’s border regions via single-cell analysis and fate-mapping. This also identified a microglial subset at the surface of the choroid plexus, in direct contact with cerebrospinal fluid.

Hannah Van Hove
Liesbet Martens
Kiavash Movahedi
Research06 May 2019
Nature Neuroscience

Volume: 22, P: 1021-1035
Epitope mapping and kinetics of CD4 T cell immunity to pneumonia virus of mice in the C57BL/6 strain

Lana Vandersarren
Cedric Bosteels
Mary J. van Helden
ResearchOpen Access14 Jun 2017
Scientific Reports

Volume: 7, P: 1-10
Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis

Dieter Tulkens
Marthe Boelens
Kris Vleminckx
Research04 Oct 2023
Leukemia

Volume: 37, P: 2404-2413
RBL1 (p107) functions as tumor suppressor in glioblastoma and small-cell pancreatic neuroendocrine carcinoma in Xenopus tropicalis

Thomas Naert
Dionysia Dimitrakopoulou
Kris Vleminckx
Research30 Jan 2020
Oncogene

Volume: 39, P: 2692-2706

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A redundant transcription factor network steers spatiotemporal Arabidopsis triterpene synthesis

Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium

Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space

Non-cell autonomous and spatiotemporal signalling from a tissue organizer orchestrates root vascular development

Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival

A coherent transcriptional feed-forward motif model for mediating auxin-sensitive PIN3 expression during lateral root development

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

Epitope mapping and kinetics of CD4 T cell immunity to pneumonia virus of mice in the C57BL/6 strain

Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis

RBL1 (p107) functions as tumor suppressor in glioblastoma and small-cell pancreatic neuroendocrine carcinoma in Xenopus tropicalis

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