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Showing 1–4 of 4 results
Advanced filters: Author: Gesine Behrens Clear advanced filters

  • Roquin targets are known to contain two types of sequence-structure motifs, the constitutive and the alternative decay elements (CDE and ADE). Here, the authors describe a linear Roquin binding element (LBE) also involved in target recognition, and show that Roquin binding affects the translation of a subset of targeted mRNAs.

    • Katharina Essig
    • Nina Kronbeck
    • Vigo Heissmeyer
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • The RNA-binding proteins Roquin-1 and Roquin-2 are essential for immune cell function and postnatal survival in mice. Here, the authors identify NUFIP2 as a cofactor of Roquin; Roquin binds and stabilizes NUFIP2 in cells while NUFIP2 regulates Roquin mRNA target recognition.

    • Nina Rehage
    • Elena Davydova
    • Vigo Heissmeyer
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15